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Freebase Commons Metaweb System Types /type

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Freebase Commons Common /common

Also known as
  • breast cancer 1, early onset
  • breast and ovarian cancer susceptibility protein 1
  • BRCA1/BRCA2-containing complex, subunit 1
  • BRCA1 and BRCA1 are a human gene and its protein product, respectively. The official symbol and the official name are maintained by the HGNC. Orthologs, styled Brca1 and Brca1, are common in other mammal species. BRCA1 is a human tumor suppressor gene, found in all humans; its protein, also called by the synonym breast cancer type 1 susceptibility protein, is responsible for repairing DNA. BRCA1 and BRCA2 are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double-strand breaks. If BRCA1 or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. Thus, although the terms "breast cancer susceptibility gene" and "breast cancer susceptibility protein" sound as if they describe an oncogene, BRCA1 and BRCA2 are normal; it is their mutation that is abnormal.

Freebase Commons Biology /biology

Gene is not asserted on this topic. Assert type now.