close

Topic

Created by benvvalk on 9/17/2008

Cladribine ^en

mid: /m/088fns notable type: /medicine/drug notable for: /medicine/drug on the web: wikipedia.org

Cladribine is a drug used to treat hairy cell leukemia and multiple sclerosis. Its chemical name is 2-chlorodeoxyadenosine. As a purine analog, it is a synthetic anti-cancer agent that also suppresses the immune system. Chemically, it mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, which interferes with the cell's ability to process DNA. It is easily destroyed by normal cells except for blood cells, with the result that it produces relatively few side effects and results in very little non-target cell loss. Wikipedia [ - ]

Add type

Metaweb System Types

Object

Common

Topic

Medicine

Drug
Medical Treatment
Drug ingredient

Freebase

Object profile

BioVenturist

BV: Product
BV: Therapeutic
Topic

benvvalk's types

NCI Term

Tag It

Concept

Schema staging

Context name
Drug extra

Object is not asserted on this topic.

ID /type/object/id

-

GUID /type/object/guid

#9202a8c04000641f8000000000843698

Type /type/object/type

Name /type/object/name

- - Edit
  - Delete
Cladribine

6 values total »

Key /type/object/key

Timestamp /type/object/timestamp

Wednesday, September 17, 2008 5:59 PM

Permission /type/object/permission

/boot/all_permission

Creator /type/object/creator

benvvalk

Attribution /type/object/attribution

benvvalk

Search /type/object/search

-

Machine ID /type/object/mid

/m/088fns

Also known as /common/topic/alias

-

Description /common/topic/description

- - Edit
  - Delete
A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)
- - Edit
  - Delete
Cladribine is a drug used to treat hairy cell leukemia and multiple sclerosis. Its chemical name is 2-chlorodeoxyadenosine. As a purine analog, it is a synthetic anti-cancer agent that also suppresses the immune system. Chemically, it mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, which interferes with the cell's ability to process DNA. It is easily destroyed by normal cells except for blood cells, with the result that it produces relatively few side effects and results in very little non-target cell loss. Wikipedia

7 values total »

Image /common/topic/image

Official website /common/topic/official_website

-

Topic equivalent webpage /common/topic/topic_equivalent_webpage

14 values total »

Social media presence /common/topic/social_media_presence

-

Topical webpage /common/topic/topical_webpage

-

Subjects /common/topic/subjects

-

Subject of /common/topic/subject_of

-

Web Link(s) (deprecated) /common/topic/webpage

-

Properties /common/topic/properties

-

Article /common/topic/article

Weblink /common/topic/weblink

-

Notable for /common/topic/notable_for

Drug

Notable types /common/topic/notable_types

Pronunciation (deprecated) /medicine/drug/pronunciation

-

ATC Code /medicine/drug/atccode

-

Drugbank /medicine/drug/drugbank

-

Pubchem (deprecated) /medicine/drug/pubchem

-

CAS Number (deprecated) /medicine/drug/cas_number

-

Pharmacological class /medicine/drug/drug_class

Purine Antimetabolite

Brands (deprecated) /medicine/drug/brands

-

Route of administration (deprecated) /medicine/drug/route_of_administration

-

Pregnancy category /medicine/drug/pregnancy_category

Pregnancy Category D (FDA)

Legal status /medicine/drug/legal_status

Prescription drug

ATC Code (deprecated) /medicine/drug/atc_code

-

Physiologic effect /medicine/drug/physiologic_effect

-

Mechanism of action /medicine/drug/mechanism_of_action

-

Marketed formulations /medicine/drug/marketed_formulations

Active moieties /medicine/drug/active_moieties

Cladribine

Active moiety of (deprecated) /medicine/drug/active_moiety_of

-

Part of compound drug (deprecated) /medicine/drug/part_of_compound_drug

-

Canonical brands /medicine/drug/canonical_brands

Leustatin

Side effects /medicine/medical_treatment/side_effects

-

Contraindications /medicine/medical_treatment/contraindications

-

Trials /medicine/medical_treatment/trials

-

Used To Treat /medicine/medical_treatment/used_to_treat

Active ingredient of formulation /medicine/drug_ingredient/active_ingredient_of_formulation

Active moiety of formulation /medicine/drug_ingredient/active_moiety_of_formulation

Active moiety of drug /medicine/drug_ingredient/active_moiety_of_drug

Cladribine

More general ingredient /medicine/drug_ingredient/more_general_ingredient

-

More specific ingredient /medicine/drug_ingredient/more_specific_ingredient

-

Object profile is not asserted on this topic. Assert type now.

Object generation time /freebase/object_profile/object_generation_time

- - Edit
  - Delete
Wednesday, May 22, 2013 8:49 PM

Link count /freebase/object_profile/link_count

-

Technology involved /base/bioventurist/product/technology_involved

-

Sales /base/bioventurist/product/sales

Amount	Currency	Year	Area	Company Reporting
-

Developed by /base/bioventurist/product/developed_by

Johnson & Johnson

Brand Names /base/bioventurist/product/brand_name

-

Stage of development /base/bioventurist/product/stage_of_development

-

Target/Biomolecule of Interest /base/bioventurist/bv_therapeutic/biomolecule_or_target

-

Indication or disease /base/bioventurist/bv_therapeutic/indication_or_disease

Therapeutics	Disease	Phase of development	Notes
-

therapeutic molecule /base/bioventurist/bv_therapeutic/composition

-

Delivery Technology /base/bioventurist/bv_therapeutic/delivery_technology

-

Approval Date /base/bioventurist/bv_therapeutic/approval_date

-

Patent Expiration /base/bioventurist/bv_therapeutic/patent_expiration

Date	Note
-

Also known as /base/bioventurist/topic/alias

-

article /base/bioventurist/topic/article

-

image /base/bioventurist/topic/image

Web Link(s) /base/bioventurist/topic/webpage

-

URI /user/benvvalk/default_domain/moby_output_descriptor/uri

- - Edit
  - Delete
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Cladribine

Pronunciation /base/schemastaging/context_name/pronunciation

IPA	Yomigana	Pinyin	Zhuyin	Text	Value of property
-

Nickname /base/schemastaging/context_name/nickname

-

Official name /base/schemastaging/context_name/official_name

-

Former name /base/schemastaging/context_name/former_name

-

Abbreviation /base/schemastaging/context_name/abbreviation

-

Culinary /base/schemastaging/context_name/culinary

-

Medical /base/schemastaging/context_name/medical

-

Chemistry /base/schemastaging/context_name/chemistry

-

Biology /base/schemastaging/context_name/biology

-

Short name /base/schemastaging/context_name/short_name

-

Original name /base/schemastaging/context_name/original_name

-

Sports /base/schemastaging/context_name/sports

-

Disputed name preferred form /base/schemastaging/context_name/disputed_name_preferred_form

-

Regional variants /base/schemastaging/context_name/regional_variants

Variant name	Preferred in regions
-

Common name /base/schemastaging/context_name/common_name

- - Edit
  - Delete
Leustatin

Pseudonym /base/schemastaging/context_name/pseudonym

-

Plural /base/schemastaging/context_name/plural

-

Comments

Hide