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  • Efavirenz is a non-nucleoside reverse transcriptase inhibitor discovered at Merck Research Laboratories. It is used as part of highly active antiretroviral therapy for the treatment of a human immunodeficiency virus type 1. For HIV infection that has not previously been treated, the United States Department of Health and Human Services Panel on Antiretroviral Guidelines currently recommends the use of efavirenz in combination with tenofovir/emtricitabine as one of the preferred NNRTI-based regimens in adults and adolescents. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to reduce the risk of HIV infection in people exposed to a significant risk. It is usually taken on an empty stomach at bedtime to reduce neurological and psychiatric adverse effects. Efavirenz was combined with the popular HIV medication Truvada, which consists of tenofovir and emtricitabine, all of which are reverse transcriptase inhibitors. This combination of three medications approved by the U.S. Food and Drug Administration in July 2006 under the brand name Atripla, provides HAART in a single tablet taken once a day. Wikipedia

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