Filter options:

Freebase Commons Metaweb System Types /type

Object is not asserted on this topic.

Freebase Commons Common /common

  • Authority and Responsibilities For each known human gene we approve a gene name and symbol (short-form abbreviation). All approved symbols are stored in the HGNC database. Each symbol is unique and we ensure that each gene is only given one approved gene symbol. It is necessary to provide a unique symbol for each gene so that we and others can talk about them, it also facilitates electronic data retrieval from publications. In preference each symbol maintains parallel construction in different members of a gene family and can also be used in other species, especially the mouse. We have already approved over 24,000 symbols; the vast majority of these are for protein-coding genes, but also include symbols for pseudogenes, non-coding RNAs, phenotypes and genomic features (see HGNC Search). Our current priority is assigning nomenclature to genes submitted to us from the Human Genome Project. In addition to this, individual new symbols are requested by scientists, journals (e.g. Genomics, Nature Genetics) and databases (e.g. Ensembl, Entrez Gene, MGD, RGD and OMIM), and groups of new symbols by those working on gene families, chromosome segments or whole chromosomes. In all cases considerable efforts are made to use a symbol acceptable to workers in the field. History Problems of nomenclature in human genetics were recognised as early as the 1960s and in 1979 full guidelines for human gene nomenclature were presented at the Edinburgh Human Genome Meeting (HGM). Since then we have continued to strike a compromise between the convenience and simplicity required for the everyday use of human gene nomenclature and the need for adequate definition of the concepts involved. The committee has grown from a single force (Dr Phyllis J. McAlpine) to a team of post-docs and bioinformaticians. For eleven years, from 1996-2007, the HGNC was chaired by Professor Sue Povey and based at University College London (UCL). In September 2007 the HGNC relocated to the European Bioinformatics Institute (EBI), to join the PANDA (Protein and Nucleotide Database) group. We regularly attend international meetings such as American Society of Human Genetics (ASHG) and Human Genome Meeting (HGM), and sometimes hold workshops in conjunction with these. This ensures that we are approving gene names in line with the needs of the scientific community, see previous workshops. Organisation We are a non-profit making body which is jointly funded by the US National Human Genome Research Institute (NHGRI) and the Wellcome Trust (UK). We operate under the auspices of HUGO, with key policy advice from an International Advisory Committee (IAC). We also use a team of specialist advisors who provide support on specific gene family nomenclature issues, and work in close collaboration with staff at MGNC. Confidentiality All enquiries are handled confidentially and unpublished information is never disclosed without explicit permission from the submitters. Other Activities Current Nomenclature Guidelines are available online Recent Publications Nome News, our bimonthly newsletter Forthcoming Meetings we will be attendingHUMOT Human and Mouse Orthologous Gene Nomenclature

Freebase Commons Internet /internet

  • pThe HUGO Gene Nomenclature Committee (HGNC) designates approved symbols for all human genes, in accordance with the Guidelines for Human Gene Nomenclature (a href=http:www.genenames.orgguidelines.htmlhttp:www.genenames.orgguidelines.htmla). It is necessary to provide a unique symbol for each gene, preferably one which maintains parallel construction in different members of a gene family and can also be used in other species, especially the mouse.ppThe HGNC is responsible for the assignment of these symbols as well as alonger and more descriptive gene name. Considerable efforts are made to use a symbol acceptable to workers in the field, but sometimes it is not possible to use exactly what has previously appeared in the literature. However, wherever the HGNC is aware of such symbols, they are listed as aliases and information on the gene in question can be retrieved by searching with the aliases and the approved symbol in the HGNC Database(a href=http:www.genenames.orgcgi-binhgnc_search.plhttp:www.genenames.orgcgi-binhgnc_search.pla). Approved gene symbols are marked as such and given priority in databases including Entrez Gene, Ensembl, GeneCards, OMIM and GenAtlas. The HGNC also works closely with a number of journals to promote standardization of gene nomenclature. These include Nature Genetics, Nature, Genomics, Human Mutation and Cytogenetic and Genome Research.p
  • Genew, the Human Gene Nomenclature Database, is the only resource that provides data for all human genes which have approved symbols. It is managed by the HUGO Gene Nomenclature Committee (HGNC) as a confidential database, containing over 16,000 records, 80% of which are represented on the Web by searchable text files. The data in Genew are highly curated by HGNC editors and gene records can be searched on the Web by symbol or name to directly retrieve information on gene symbol, gene name, cytogenetic location, OMIM number and PubMed ID. Data are integrated with other human gene databases e.g. GDB, LocusLink and SWISS-PROT and approved gene symbols are carefully co-ordinated with the Mouse Genome Database (MGD). Approved gene symbols are available for querying and browsing at: a
URL pattern