close

  
Filter options:

Freebase Commons Metaweb System Types /type

Object is not asserted on this topic.
Key

Freebase Commons Common /common

Description
  • A substituted benzamide and a derivative of para-aminobenzoic acid (PABA) that is structurally related to procainamide, with gastroprokinetic and antiemetic effects. Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation effect on gastrointestinal smooth muscle. This enhances the response of the gastrointestinal smooth muscle to cholinergic stimulation, thereby leading to an increase of gastric emptying into the intestines. Metoclopramide may also strengthen the lower esophagus sphincter, thereby preventing acid reflux. This agent antagonizes D2 dopamine receptors in chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting.
  • Metoclopramide is an antiemetic and gastroprokinetic agent. It belongs to a group of medicines called dopaminergic blockers. It is commonly used to treat nausea and vomiting, to facilitate gastric emptying in people with gastroparesis, and as a treatment for the gastric stasis often associated with migraine headaches. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Freebase Commons Medicine /medicine

Freebase Commons Chemistry /chemistry

Chemical Element is not asserted on this topic. Assert type now.

Comments

Hide