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  • A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals.
  • Olsalazine is an anti-inflammatory drug used in the treatment of inflammatory bowel disease such as ulcerative colitis. It is sold under the name Dipentum. The chemical name is 3,3' -azobis salicylic acid. It is sold as the disodium salt. Like balsalazide, olsalazine is believed to deliver mesalazine, or 5-aminosalicylic acid, past the small intestine, directly to the large intestine, which is the active site of disease in ulcerative colitis.

Freebase Commons Medicine /medicine