close

  
Filter options:

Freebase Commons Metaweb System Types /type

Object is not asserted on this topic.
Key

Freebase Commons Common /common

Description
  • A synthetic piperidine ester with opioid analgesic activity. Meperidine mimics the actions of endogenous neuropeptides via opioid receptors, thereby producing the characteristic morphine-like effects on the mu-opioid receptor, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence.
  • Pethidine or meperidine is a once popular synthetic opioid analgesic of the phenylpiperidine class. Synthesized in 1939 as a potential anticholinergic agent by the German chemist Otto Eislib, its analgesic properties were first recognized by Otto Schaumann while working for IG Farben, Germany. Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as a hydrochloride salt in tablets, as a syrup, or by intramuscular, subcutaneous or intravenous injection. For much of the 20th century, pethidine was the opioid of choice for many physicians; in 1975 60% of doctors prescribed it for acute pain and 22% for chronic severe pain. Compared to morphine, pethidine was thought to be safer, carry a lower risk of addiction and to be superior in treating the pain associated with biliary spasm or renal colic due to its putative anticholinergic effects. It was later discovered that these were all myths and that it carried an at least equal risk of addiction, possessed no advantageous effects on biliary spasm or renal colic compared to other opioids and that, due to its toxic metabolite, norpethidine, it was more toxic than other opioids, especially during long-term use. It was also discovered that the norpethidine metabolite had serotonergic effects which means that pethidine could, unlike most opioids, contribute to serotonin syndrome. Wikipedia

Freebase Commons Medicine /medicine

Freebase Commons Chemistry /chemistry

Chemical Compound is not asserted on this topic. Assert type now.
Chemical Element is not asserted on this topic. Assert type now.

Comments

Hide