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  • The Reference Sequence (RefSeq) database is a non-redundant collection of richly annotated DNA, RNA, and protein sequences from diverse taxa. The collection includes sequences from plasmids, organelles, viruses, archaea, bacteria, and eukaryotes. Each RefSeq represents a single, naturally occurring molecule from one organism. The goal is to provide a comprehensive, standard dataset that represents sequence information for a species. It should be noted, though, that RefSeq has been built using data from public archival databases only. RefSeq biological sequences (also known as RefSeqs) are derived from GenBank records but differ in that each RefSeq is a synthesis of information, not an archived unit of primary research data. Similar to a review article in the literature, a RefSeq represents the consolidation of information by a particular group at a particular time. RefSeqs are available without restriction and can be retrieved in several different ways such as: searching NCBI's databases including Nucleotide, Protein, Gene, and Map Viewer; searching with a sequence via BLAST; doing an FTP download; or through links from other NCBI resources including Gene, Map Viewer, and PubMed.
Description
  • The NCBI Reference Sequence project (RefSeq) will provide reference sequencestandards for the naturally occurring molecules of the central dogma, fromchromosomes to mRNAs to proteins. RefSeq standards provide a foundation for thefunctional annotation of the human genome. They provide a stable referencepoint for mutation analysis, gene expression studies, and polymorphismdiscovery.pScope: Currently, RefSeq records are provided for the following molecule typesand genomes:PREMolecule Accession Format Genome Complete Genome NC_###### Organelle Complete Chromosome NC_###### Saccharomyces cerevisiae Genomic Contig NT_###### Homo sapiens Mus musculusmRNA NM_###### Limited Vertebrate Homo sapiens Mus musculus Rattus norvegicus Protein NP_###### All of the abovePRE
  • The National Center for Biotechnology Information Reference Sequence (RefSeq) database provides curated non-redundant sequence standards for genomic regions, transcripts (including splice variants), and proteins. brRecords are compiled using a combined approach of collaboration, automated methods, prediction, and curation and are extensively integrated with other NCBI resources facilitating navigation and discovery. RefSeq records represent the current best view of genomes and their transcript andor protein products.

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