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  • Saos-2 is a cell line derived from the primary osteosarcoma of an 11-year-old Caucasian girl in 1973 by Fogh et al. In 1987 Rodan et al. determined that Saos-2 cells "possess several osteoblastic features and could be useful as a permanent line of human osteoblast-like cells and as a source of bone-related molecules." Besides their worldwide availability, some of the advantages for using Saos-2 cell line are that they have well-documented characterization data, the possibility to obtain large amounts of cells in short time, and the fact that Saos-2 cells can be fully differentiated in a manner that the osteoblastic cells naturally do. The latter point is described particularly as "the ability of Saos-2 cells to deposit a mineralization-competent extracellular matrix", which makes these cells a valuable model for studying events associated with the late osteoblastic differentiation stage in human cells.

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