Filter options:

Freebase Commons Metaweb System Types /type

Object is not asserted on this topic.

Freebase Commons Common /common

  • The Fukuyama indole synthesis is a versatile tin mediated chemical reaction that results in the formation of 2,3-disubstituted indoles. A practical one-pot reaction that can be useful for the creation of disubstituted indoles. Most commonly tributyltin hydride is utilized as the reducing agent, with azobisisobutyronitrile as a radical initiator. Triethylborane can also be used as a radical initiator. The reaction can begin with either an o-isocyanostyrene or a 2-alkenylthioanilide derivative, both forming the indole through Radical cyclization via an alpha-stannoimidoyl radical. The R group can be a range of both basic and acidic sensitive functional groups such as esters, THP ethers, and beta-lactams. In addition the reaction is not stereo specific, in that both the cis and trans isoform can be used to obtain the desired product.