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  • Lactonase is a metalloenzyme, produced by certain species of bacteria, which targets and inactivates acylated homoserine lactones. Many species of Proteobacteria from the alpha, beta and gamma classes have been shown to produce acylated homoserine lactones, which are small hormone-like molecules commonly used as communication signals between bacterial cells in a population to regulate certain gene expression and phenotypic behaviours. This type of gene regulation is known as quorum sensing.