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  • Dextrallorphan is an opioid derivative drug of the morphinan class and is used in scientific research. It acts as a σ₁ receptor agonist and NMDA receptor antagonist. It has no significant affinity for the σ₂, μ-opioid, or δ-opioid receptor, or for the serotonin or norepinephrine transporter. As an NMDA receptor antagonist, in vivo, it is approximately twice as potent as dextromethorphan, and five-fold less potent than dextrorphan.