Created by
wdsnow
on
11/10/2011
Molecular Imaging of Matrix Metalloproteinase Expression Using Chlorotoxin en
Researchers at Stanford have discovered a way to use labeled chlorotoxin to non-invasively assist in early cancer detection. Chlorotoxin (Cltx) was labeled with 18F via direct attachment using a chemical compound or indirect attachment using a chelator. 18F-fluorobenzoate conjugated chlorotoxin (18F-FB-Cltx) was prepared. Biodistribution and micro PET imaging of 18F-FB-Cltx in the mice bearing matrix metalloproteinase (MMP-2) positive tumors were performed. The results clearly show that 18F-FB-Cltx accumulates in the tumors in vivo. In addition, this process can also be used to image, monitor and diagnose MMP-2 positive diseases, such as, myocardial infarction, rheumatoid arthritis and atherosclerosis. [ - ]
Links
| Subject | Predicate | Object/Value | Creator | Attribution | Timestamp | |
|---|---|---|---|---|---|---|
| 1 | /m/0hdn2jb | /common/topic/description | Researchers at Stanford have discovered a way to use labeled chlorotoxin to non-invasively assist in early cancer detection. Chlorotoxin (Cltx) was labeled with 18F via direct attachment using a chemical compound or indirect attachment using a chelator. 18F-fluorobenzoate conjugated chlorotoxin (18F-FB-Cltx) was prepared. Biodistribution and micro PET imaging of 18F-FB-Cltx in the mice bearing matrix metalloproteinase (MMP-2) positive tumors were performed. The results clearly show that 18F-FB-Cltx accumulates in the tumors in vivo. In addition, this process can also be used to image, monitor and diagnose MMP-2 positive diseases, such as, myocardial infarction, rheumatoid arthritis and atherosclerosis. /lang/en | /user/wdsnow | none | |
| 2 | /m/0hdn2jb | /law/invention/date_of_invention | 2006 | /user/scottvanduyne | none | |
| 3 | /m/0hdn2jb | /common/topic/topical_webpage | http://otlportal.stanford.edu/techfinder/technology/ID=24968 | none | /user/gardening_bot/attr/563 | |
| 4 | /m/0hdn2jb | /law/invention/inventor | /m/03wwphh Sanjiv Sam Gambhir | /user/wdsnow | none | |
| 5 | /m/0hdn2jb | /law/invention/inventor | /m/0fp9c63 Zhen Cheng | /user/wdsnow | none | |
| 6 | /m/0hdn2jb | /base/visleg/labeled/subject | S06-277 /lang/en | /user/wdsnow | none | |
| 7 | /m/0hdn2jb | /base/visleg/labeled/subject | cancer screening /lang/en | /user/wdsnow | none | |
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| 12 | /m/0hdn2jb | /common/topic/webpage | /m/0hdn2rl cvt | /user/wdsnow | none | |
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| 16 | /m/0hdn2jb | /type/object/type | /projects/project_focus | /user/wdsnow | none | |
| 17 | /m/0hdn2jb | /type/object/name | Molecular Imaging of Matrix Metalloproteinase Expression Using Chlorotoxin /lang/en | /user/wdsnow | none | |
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