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  • Effective means of imaging for the localization or extent of pain in clinical patients are not available today. A contrast agent such as an iron particle can be used together with an MR method made sensitive to the presence and extent of the contrast agent to reveal the site of inflammation, nerve injury or neuropathic pain. The invention embodies an imaging methodology useful in clinical diagnosis of real or perceived patient pain that may lead to non-invasive testing of new drugs for pain relief or to facilitate image-guided therapies or as a monitor to assess and guide patient self-management of pain.