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| x name | x image | x Therapeutics | x article | ||
| x Therapeutics | x Phase of development | x Notes | |||
| x Metabolic Disease | |||||
| x Neurological Disease | MK-4305 | Phase I Clinical Trial | |||
| MK-8998 | Phase I Clinical Trial | ||||
| x Psychiatric Disorders | MK-5757 | Phase I Clinical Trial |
psychological or physiological pattern that occurs in an individual and is usually associated with distress or disability that is not expected as part of normal development or culture.
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| MK-2866 | Phase II Clinical Trial | ||||
| x Glaucoma |
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PF-3,187,207 | Phase II Clinical Trial |
Glaucoma is a group of diseases that affect the optic nerve and involves a loss of retinal ganglion cells in a characteristic pattern. It is a type of optic neuropathy. Raised intraocular pressure is a significant risk factor for developing glaucoma...
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| PF-4,217,329 | Phase II Clinical Trial | ||||
| Latanoprost | On the market | ||||
| Cosopt | On the market | ||||
| x Inflammation |
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CC-11050 | Phase I Clinical Trial |
Inflammation (Latin, inflammatio, a setting on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the...
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| x Pancreatic cancer |
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TheraPlas | Pre-clinical development |
Pancreatic cancer is a malignant neoplasm of the pancreas. Each year in the United States, about 42,470 individuals are diagnosed with this condition and 35,240 die from the disease. The prognosis is relatively poor but has improved; the three-year...
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| Axitinib | Phase III Clinical Trial | ||||
| MGCD0103 | Phase II Clinical Trial | ||||
| Abraxane | Phase III Clinical Trial | ||||
| ARC 100 | Phase II Clinical Trial | ||||
| more ▼ | |||||
| x Brain Cancer | TheraPlas | Pre-clinical development | |||
| x Ovarian cancer |
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TheraPlas | Phase I Clinical Trial |
Ovarian cancer is a cancerous growth arising from different parts of the ovary.
The most common form of ovarian cancer (≥80%) arises from the outer lining (epithelium) of the ovary.. However, recent evidence shows cells that line the Fallopian tube ...
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| Pertuzumab | Phase II Clinical Trial | ||||
| Volociximab | Phase II Clinical Trial | ||||
| ALKERAN | On the market | ||||
| BSI-201 | Phase II Clinical Trial | ||||
| more ▼ | |||||
| x Lung cancer |
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TheraPlas | Pre-clinical development |
Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. This growth may lead to metastasis, which is the invasion of adjacent tissue and infiltration beyond the lungs. The vast majority of primary lung cancers are carcinomas of...
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| Cisplatin Lipid Complex | Phase I Clinical Trial | ||||
| Axitinib | Phase II Clinical Trial | ||||
| Sunitinib | Phase III Clinical Trial | ||||
| PF-3,512,676 | Phase II Clinical Trial | ||||
| more ▼ | |||||
| x Inflammatory Disease | CEL_p38 | Pre-clinical development | |||
| x Lymphoma |
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MGCD0103 | Phase II Clinical Trial |
Lymphoma is a cancer that begins in the lymphocytes of the immune system and presents as a solid tumor of lymphoid cells. They often originate like balls in lymph nodes, presenting as an enlargement of the node (a tumor). Lymphomas are closely...
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| x B-cell lymphoma | Rituximab | On the market |
The B-cell lymphomas are types of non-Hodgkin lymphoma affecting B cells. It develops more frequently in immunocompromised individuals (such as those with AIDS.)
There are fourteen kinds of lymphomas involving B cells.
Five account for nearly three...
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| Galiximab | Phase III Clinical Trial | ||||
| Milatuzumab | Phase I Clinical Trial | ||||
| Epratuzumab | Phase II Clinical Trial | ||||
| Lumiliximab | Phase III Clinical Trial | ||||
| more ▼ | |||||
| x Androgenetic alopecia |
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Propecia | On the market |
Androgenic alopecia (also known as androgenetic alopecia or alopecia androgenetica) is a common form of hair loss in both female and male humans, chimpanzees, and orangutans. In male humans in particular, this condition is also commonly known as...
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| x Dermatological Diseases | |||||
| x Diabetes mellitus |
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PF-4,603,629 | Phase I Clinical Trial |
Diabetes mellitus (pronounced /ˌdaɪ.əˈbiːtiːz/ or /ˌdaɪ.əˈbiːtɨs/; /mɨˈlaɪtəs/ or /ˈmɛlɨtəs/)—often referred to simply as diabetes—is a condition in which the body either does not produce enough, or does not properly respond to, insulin, a hormone...
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| MK-0941 | Phase I Clinical Trial | ||||
| MK-2662 | Phase I Clinical Trial | ||||
| MK-8245 | Phase I Clinical Trial | ||||
| MK-0893 | Phase II Clinical Trial | ||||
| more ▼ | |||||
| x Ischemic Stroke | |||||
| x Gastrointestinal Disorders | CP-751,871 | Phase II Clinical Trial |
Diseases of the digestive tract (oral cavity to anus) and associated organs (salivary glands, liver, pancreas).
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| x Oncology |
Oncology is the branch of medicine dealing with tumors (cancer). A medical professional who practices oncology is an oncologist. The term originates from the Greek "Ογκολογία" derived from onkos (όγκος), meaning bulk, mass, or tumor, and the suffix ...
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| x Viral Infection | |||||
| x Neurodegenerative disease |
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Neurodegenerative disease (Greek νέυρο-, néuro-, "nerval" and Latin dēgenerāre, "to decline" or "to worsen") is a condition in which cells of the brain and spinal cord are lost. The brain and spinal cord are composed of neurons that perform...
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| x Huntington's disease |
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ALN-HTT | Pre-clinical development |
Huntington's disease, chorea, or disorder (HD), is an incurable neurodegenerative genetic disorder that affects muscle coordination and some cognitive functions, typically becoming noticeable in middle age. It is the most common genetic cause of...
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| x Amyotrophic lateral sclerosis |
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Amyotrophic lateral sclerosis is a form of motor neuron disease. ALS, sometimes called Maladie de Charcot, is a progressive, fatal, neurodegenerative disease caused by the degeneration of motor neurons, the nerve cells in the central nervous system...
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| x Lung transplantation |
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Lung transplantation is a surgical procedure in which a patient's diseased lungs are partially or totally replaced by lungs which come from a donor. While lung transplants carry certain associated risks, they can also extend life expectancy and...
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| x Bladder cancer |
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OGX-427 | Phase I Clinical Trial |
Bladder cancer refers to any of several types of malignant growths of the urinary bladder. It is a disease in which abnormal cells multiply without control in the bladder. The bladder is a hollow, muscular organ that stores urine; it is located in...
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| OGX-427 | Phase I Clinical Trial | ||||
| OGX-225 | Pre-clinical development | ||||
| OGX-225 | Pre-clinical development | ||||
| x Venous thrombosis | Betrixaban | Phase II Clinical Trial |
A venous thrombosis is a blood clot that forms within a vein. (Thrombosis is a specific medical term for a blood clot that remains in the place where it formed.)
Superficial venous thromboses can cause discomfort but generally do not cause serious...
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| Apixaban | Phase III Clinical Trial | ||||
| Apixaban | Phase II Clinical Trial | ||||
| x Thrombosis | PRT06O128 | Phase II Clinical Trial |
Thrombosis (Greek θρόμβωσις) is the formation of a blood clot (thrombus) inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel is injured, the body uses platelets and fibrin to form a blood clot,...
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| PD-348,292 | Phase II Clinical Trial | ||||
| x Infectious disease |
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MK-3281 | Phase I Clinical Trial |
An infectious disease is a clinically evident disease resulting from the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions....
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| MK-4965 | Phase I Clinical Trial | ||||
| MK-7009 | Phase I Clinical Trial | ||||
| MK-8122 | Phase I Clinical Trial | ||||
| V512 | Phase I Clinical Trial | ||||
| more ▼ | |||||
| x Cystic fibrosis Infections | Arikace | Phase II Clinical Trial | |||
| x Osteosarcoma Lung Metastases | Cisplatin Lipid Complex | Phase I Clinical Trial | |||
| x Bronchoalveolar Carcinoma | Cisplatin Lipid Complex | Phase I Clinical Trial | |||
| x Heart failure |
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Enalapril | On the market |
Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction ...
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| MK-8669 | Phase III Clinical Trial | ||||
| MK-7418 | Phase III Clinical Trial | ||||
| ADENTRI | Phase II Clinical Trial | ||||
| x Bacterial Infection | Sulopenem oral prodrug | Phase I Clinical Trial | |||
| sulopenem IV | Phase I Clinical Trial | ||||
| Azithromycin | On the market | ||||
| Linezolid | On the market | ||||
| Imipenem/cilastatin | On the market | ||||
| more ▼ | |||||
| x Type 1 Diabetes Mellitus |
Diabetes mellitus characterized by insulin deficiency, sudden onset, severe hyperglycemia, rapid progression to ketoacidosis, and death unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
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| x Diabetic retinopathy |
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RTP801i-14 | Pre-clinical development |
Diabetic retinopathy is retinopathy (damage to the retina) caused by complications of diabetes mellitus, which can eventually lead to blindness. It is an ocular manifestation of systemic disease which affects up to 80% of all patients who have had...
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| Bevasiranib | Phase I Clinical Trial | ||||
| ACU-HHY-011 | Pre-clinical development | ||||
| x Eczema |
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Eczema is a disease in a form of dermatitis, or inflammation of the epidermis. The term eczema is broadly applied to a range of persistent skin conditions. These include dryness and recurring skin rashes that are characterized by one or more of...
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| x Ulcerative colitis |
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GEN - Anti-Beta7 | Phase I Clinical Trial |
Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative colitis is a form of colitis, a disease of the intestine, specifically the large intestine or colon, that includes characteristic ulcers, or open...
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| Infliximab | On the market | ||||
| x Atherosclerosis |
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CP-800,569 | Phase I Clinical Trial |
Atherosclerosis (also known as Arteriosclerotic Vascular Disease or ASVD) is the condition in which an artery wall thickens as the result of a build-up of fatty materials such as cholesterol. It is a syndrome affecting arterial blood vessels, a...
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| PF-3,185,043 | Phase I Clinical Trial | ||||
| MK-1903 | Phase I Clinical Trial | ||||
| MK-6213 | Phase I Clinical Trial | ||||
| MK-0859 | Phase II Clinical Trial | ||||
| more ▼ | |||||
| x Inflammatory bowel disease |
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CEQ600 | Pre-clinical development |
In medicine, inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis..
The main forms of IBD are Crohn's disease and ulcerative...
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| x Cervical cancer |
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Cervical cancer is malignant neoplasm of the cervix uteri or cervical area. It may present with vaginal bleeding but symptoms may be absent until the cancer is in its advanced stages. Treatment consists of surgery (including local excision) in early...
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| x Wet Age-Related Macular Degeneration | Macugen | On the market | |||
| Ranibizumab | On the market | ||||
| Bevasiranib | Phase III Clinical Trial | ||||
| ACU-HHY-011 | Pre-clinical development | ||||
| x Sleep apnea |
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Armodafinil | On the market |
Sleep apnea (or sleep apnoea in British English) is a sleep disorder characterized by pauses in breathing during sleep. Each episode, called an apnea (Greek: ἄπνοια (ápnoia), from α- (a-), privative, πνέειν (pnéein), to breathe), lasts long enough...
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| x Vascular Repair | |||||
| x Non-Small Cell Lung Carcinoma |
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On the market |
A group of at least three distinct histological types of lung cancer, including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy. --2002
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| Carboplatin | On the market | Indicated for unresectable, locally advanced, recurrent or metastatic non-squamous, non-small cell lung cancer. | |||
| Paclitaxel | Phase III Clinical Trial | ||||
| Bevacizumab | Phase II Clinical Trial | ||||
| Motesanib diphosphate | Phase III Clinical Trial | ||||
| more ▼ | |||||
| x Obesity |
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CP-945,598 | Phase III Clinical Trial |
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems. Body mass index (BMI), a measurement which...
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| CP-866,087 | Phase II Clinical Trial | ||||
| CE-326,597 | Phase II Clinical Trial | ||||
| PF-2,575,799 | Phase I Clinical Trial | ||||
| PF-4,325,667 | Phase I Clinical Trial | ||||
| more ▼ | |||||
| x Pediatrics |
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Pediatrics is the branch of medicine that deals with the medical care of infants, children, and adolescents. The upper age limit of such patients ranges from age 12 to 21, depending on the country. A medical practitioner who specializes in this area...
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| x Veterinary medicine |
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Veterinary medicine is the application of medical, diagnostic, surgical, dental, and therapeutic principles to companion, domestic, exotic, wildlife, and production animals. Veterinary science is vital to the study and protection of animal...
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| x Diabetes mellitus type 2 |
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Exenatide | On the market |
Diabetes mellitus type 2 or type 2 diabetes (formerly called non-insulin-dependent diabetes mellitus (NIDDM), or adult-onset diabetes) is a disorder that is characterized by high blood glucose in the context of insulin resistance and relative...
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| PF-734,200 | Phase II Clinical Trial | ||||
| Sitagliptin | On the market | ||||
| Janumet | On the market | ||||
| Acarbose | On the market | ||||
| more ▼ | |||||
| x Iron overload disorder |
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In medicine, iron overload (also known as haemochromatosis) indicates accumulation of iron in the body due to any cause.
Historically, the term "haemochromatosis" was initially used to refer to what is now more specifically called haemochromatosis...
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| x In vitro fertilisation |
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In vitro fertilisation (IVF) is a process by which egg cells are fertilised by sperm outside the womb, in vitro. IVF is a major treatment in infertility when other methods of assisted reproductive technology have failed. The process involves...
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| x Drug resistance |
Drug resistance is the reduction in effectiveness of a drug in curing a disease or improving a patient's symptoms. When the drug is not intended to kill or inhibit a pathogen, then the term is equivalent to dosage failure or drug tolerance. More...
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| x Chronic Obstructive Pulmonary Disease |
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UK-432,097 | Phase II Clinical Trial |
Chronic obstructive pulmonary disease (COPD) refers to chronic bronchitis and emphysema, a pair of two commonly co-existing diseases of the lungs in which the airways become narrowed. This leads to a limitation of the flow of air to and from the...
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| PF-489,791 | Phase I Clinical Trial | ||||
| PH-797,804 | Phase II Clinical Trial | ||||
| x Pulmonary hypertension |
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PF-489,791 | Phase I Clinical Trial |
In medicine, pulmonary hypertension (PH or PHT) is an increase in blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, together known as the lung vasculature, leading to shortness of breath, dizziness, fainting, and...
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| Flolan | On the market | ||||
| x Atrial fibrillation |
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Apixaban | Phase III Clinical Trial |
Atrial fibrillation (AF or afib) is the most common cardiac arrhythmia (abnormal heart rhythm) and involves the two upper chambers (atria) of the heart. Its name comes from the fibrillating (i.e. quivering) of the heart muscles of the atria, instead...
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| x Acute coronary syndrome |
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Apixaban | Phase II Clinical Trial |
An acute coronary syndrome (ACS) is a set of signs and symptoms (syndrome) related to the heart. ACS is compatible with a diagnosis of acute myocardial ischemia, but it is not pathognomonic.
The sub-types of acute coronary syndrome include unstable...
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| x Bone healing |
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CP-533,536 | Phase II Clinical Trial |
Bone healing, or fracture healing, is a proliferative physiological process in which the body facilitates the repair of a bone fracture.
Generally bone fracture treatment consists of a doctor pushing dislocated bones back into place via relocation...
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| x Gastroesophageal reflux disease |
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PF-885,706 | Phase II Clinical Trial |
Gastroesophageal reflux disease (GERD), gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease is defined as chronic symptoms or mucosal damage produced by the abnormal reflux in the esophagus.
This is commonly due...
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| PF-4,548,043 | Phase I Clinical Trial | ||||
| PF-2,391,677 | Phase I Clinical Trial | ||||
| Omeprazole | On the market | ||||
| x Liver disease |
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PF-4,136,309 | Phase I Clinical Trial |
Liver disease (also called hepatic disease) is a broad term describing any single number of diseases affecting the liver. Many are accompanied by jaundice caused by increased levels of bilirubin in the system. The bilirubin results from the breakup...
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| x Lower urinary tract symptoms | UK-369,003 | Phase II Clinical Trial |
Lower Urinary Tract Symptoms (LUTS) are a common problem affecting approximately 40% of older men. LUTS is a recent term for what used to be known as prostatism.
Symptoms can be categorised into:
As the symptoms are common and non-specific, LUTS is...
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| x Sexual Health | PF-446,687 | Phase I Clinical Trial | |||
| x Urinary incontinence | PF-3,274,167 | Phase I Clinical Trial |
Loss of bladder control is a symptom of certain diseases.
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