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| x name | x image | x Target/Biomolecule of Interest | x Indication or disease | x article | |
|---|---|---|---|---|---|
| x Therapeutics | x Disease | ||||
| x Panitumumab | Epidermal growth factor receptor | Colorectal cancer |
Panitumumab (INN), formerly ABX-EGF, is a fully human monoclonal antibody specific to the epidermal growth factor receptor (also known as EGF receptor, EGFR, ErbB-1 and HER1 in humans).
Panitumumab is manufactured by Amgen and marketed as Vectibix....
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| Colorectal cancer | |||||
| Head and neck cancer | |||||
| x Cinacalcet |
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Secondary hyperparathyroidism |
Cinacalcet (INN) is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. It is sold by Amgen under the trade...
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| Cardiovascular disease | |||||
| x Darbepoetin alfa | Erythropoietin | Anemia |
Darbepoetin alfa (rINN) (pronounced /dɑrbəˈpɔɪtɨn/) is a synthetic form of erythropoietin. It stimulates erythropoiesis (increases red blood cell levels) and is used to treat anemia, commonly associated with chronic renal failure and cancer...
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| x Etanercept |
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Rheumatoid arthritis |
Etanercept (Enbrel) is a drug that treats autoimmune diseases by interfering with the TNF receptor (a part of the immune system) by acting as a TNF inhibitor.
Etanercept is a fusion protein produced through expression of recombinant DNA. That is, it...
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| Ankylosing spondylitis | |||||
| Psoriatic arthritis | |||||
| Plaque Psoriasis | |||||
| Juvenile idopathic arthritis | |||||
| x Palifermin |
Palifermin (Kepivance, Biovitrum) is a human recombinant keratinocyte growth factor (KGF) produced in Escherichia coli.
Palifermin costs approximately 5,000 Euros per treatment for a 70 kg patient
When patients with blood cancers undergo high dose...
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| x Anakinra |
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Anakinra (Kineret) is a drug used to treat rheumatoid arthritis.
Anakinra is an interleukin-1 (IL-1) receptor antagonist. Anakinra blocks the biologic activity of naturally occurring IL-1, including inflammation and cartilage degradation associated...
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| x Pegfilgrastim | Granulocyte colony-stimulating factor | Febrile neutropenia |
Pegfilgrastim is a immunostimulator which functions as a PEGylated granulocyte colony-stimulating factor. Amgen manufactures pegfilgrastim under the brand name Neulasta.
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| x Filgrastim |
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Granulocyte colony-stimulating factor | Neutropenia |
Filgrastim is a granulocyte colony-stimulating factor (G-CSF) analog used to stimulate the proliferation and differentiation of granulocytes. It is produced by recombinant DNA technology. The gene for human granulocyte colony-stimulating factor is...
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| x TNKase | Myocardial infarction | ||||
| x ACTIVASE | |||||
| x Nutropin | |||||
| x Dornase alfa | |||||
| x Abelcet | Fungal Infections | ||||
| x Amphotec | Fungal Infections | ||||
| x Ambisome | Fungal Infections | ||||
| x DaunoXome | Kaposi's sarcoma | ||||
| x Doxil/Caefyx | Fungal Infections | ||||
| x Depocyt | Cancer | ||||
| x Epaxal Berna | Hepatitis A | ||||
| x Inflexal V Berna | Influenza | ||||
| x Myocet | Breast cancer | ||||
| x Visudyne | Age-Related Macular Degeneration | ||||
| x Estrasorb | Estradiol | Menopause | |||
| x Adagen | Immunodeficiency | ||||
| x Oncaspar | Leukemia | ||||
| x PEGASYS | Hepatitis C |
Pegylated interferon alfa-2a (40 kDa; commercial name Pegasys) is an antiviral drug discovered at the pharmaceutical company F. Hoffmann-La Roche; it has a dual mode of action - both antiviral and on the immune system. The additon of polyethylene...
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| x PEG-Intron | Hepatitis C | ||||
| x Macugen | Vascular endothelial growth factor | Wet Age-Related Macular Degeneration | |||
| x Somavert | Acromegaly | ||||
| x Copaxone | |||||
| x Renagel | Chronic renal failure | ||||
| x Emend | Nausea and Vomiting Caused by Chemotherapy |
(aprepitant) is an antiemetic that can be used in conjunction with other antiemetic medications to prevent nausea and vomiting in patients undergoing chemotherapy in a condition known as chemotherapy-induced nausea and vomiting or CINV. The drug is...
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| x Megace ESc | |||||
| x Rapamune | Transplant rejection | ||||
| x Tricorc | |||||
| x Triglidec | |||||
| x Abraxane | Metastatic Breast Cancer | ||||
| Non-Small Cell Lung Carcinoma | |||||
| Ovarian cancer | |||||
| Melanoma | |||||
| Prostate cancer | |||||
| more ▼ | |||||
| x Infliximab |
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Tumor necrosis factor | Plaque Psoriasis |
Infliximab (Remicade) is a monoclonal antibody against TNFα. It is used to treat autoimmune diseases.
Infliximab has been approved by the U.S. Food and Drug Administration for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis,...
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| Pediatric Crohn's Disease | |||||
| Crohn's disease | |||||
| Psoriatic arthritis | |||||
| Rheumatoid arthritis | |||||
| more ▼ | |||||
| x Rituximab | CD20 | Rheumatoid arthritis |
Rituximab, sold under the trade names Rituxan and MabThera, is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells. Rituximab is used in the treatment of many lymphomas, leukemias, and some...
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| Non-Hodgkin lymphoma | |||||
| B-cell lymphoma | |||||
| Systemic lupus erythematosus | |||||
| ANCA-associated vasculitides | |||||
| more ▼ | |||||
| x Trastuzumab |
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HER2/neu | Breast cancer |
Trastuzumab (Herceptin) is a monoclonal antibody that interferes with the HER2/neu receptor.
The HER receptors are proteins that are embedded in the cell membrane and communicate molecular signals from outside the cell to inside the cell, and turn...
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| HER2-Positive Ductal Carcinoma | |||||
| x Palivizumab | F protein of RSV | Human respiratory syncytial virus |
Palivizumab (brand name Synagis or Abbosynagis) is a monoclonal antibody produced by recombinant DNA technology. It is used in the prevention of Respiratory Syncytial Virus (RSV) infections. It is recommended for certain infants that are high-risk ...
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| x Adalimumab |
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Tumor necrosis factor | Chronic Childhood Arthritis |
Adalimumab (HUMIRA, Abbott) is the third TNF inhibitor, after infliximab and etanercept, to be approved in the United States. Like infliximab and etanercept, adalimumab binds to TNFα, preventing it from activating TNF receptors; adalimumab was...
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| Psoriasis | |||||
| Psoriatic arthritis | |||||
| Ankylosing spondylitis | |||||
| Rheumatoid arthritis | |||||
| more ▼ | |||||
| x Bevacizumab | Vascular endothelial growth factor | Fluorouracil | Colorectal cancer |
Bevacizumab (trade name Avastin, Genentech/Roche) is a humanized monoclonal antibody that recognises and blocks vascular endothelial growth factor (VEGF). VEGF is a chemical signal that stimulates the growth of new blood vessels (angiogenesis)....
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| Carboplatin | Non-Small Cell Lung Carcinoma | ||||
| Paclitaxel | Breast cancer | ||||
| Paclitaxel | B-cell lymphoma | ||||
| Non-Squamous Non-Small Cell Lung Cancer | |||||
| more ▼ | |||||
| x Abciximab | Glycoprotein IIb/IIIa Receptor | Ischemia |
Abciximab (previously known as c7E3 Fab), manufactured by Centocor and distributed by Eli Lilly under the trade name ReoPro, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent...
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| x Omalizumab |
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Immunoglobulin E | Asthma |
Omalizumab (Xolair, Genentech / Novartis) is a humanized antibody drug approved for patients with moderate-to-severe or severe allergic asthma, which is caused by hypersensitivity reactions to certain harmless environmental substances. Omalizumab's...
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| Pediatric Asthma | |||||
| x Alemtuzumab |
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CD52 | Chronic lymphocytic leukemia |
Alemtuzumab (marketed as Campath, MabCampath or Campath-1H) is a monoclonal antibody used in the treatment of chronic lymphocytic leukemia (CLL), cutaneous T cell lymphoma (CTCL) and T-cell lymphoma.
Alemtuzumab targets CD52, a protein present on...
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| B-cell lymphoma | |||||
| Multiple sclerosis | |||||
| x Muromonab | CD3 receptor | Transplant rejection |
Muromonab-CD3 (generic name) is a monoclonal antibody (mAb), also known as Orthoclone OKT3 (Brand name). It is a mouse-derived (murine) monoclonal antibody that specifically binds to the CD3 (T3) protein found on the surface of T cells.
Of...
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| x Efalizumab | CD11a | Psoriasis |
Efalizumab (trade name Raptiva, Genentech, Merck Serono) is a medication designed to treat psoriasis. As its name implies, it is a recombinant humanized monoclonal antibody that binds to CD11a and acts as an immunosuppressant. It is administered...
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| Kidney transplantation | |||||
| x Basiliximab |
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Interleukin 2 receptor, alpha | Transplant rejection |
Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a Novartis...
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| x Gemtuzumab ozogamicin | CD33 | Acute myeloid leukemia |
Gemtuzumab ozogamicin (marketed by Wyeth as Mylotarg) is a monoclonal antibody used to treat acute myelogenous leukemia.
It is a monoclonal antibody to CD33 linked to a cytotoxic agent from the class of calicheamicins. CD33 is expressed in most...
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| x Ibritumomab tiuxetan | CD20 | Non-Hodgkin lymphoma |
Ibritumomab tiuxetan, sold under the trade name Zevalin, is a monoclonal antibody radioimmunotherapy treatment for some forms of B cell non-Hodgkin's lymphoma, a myeloproliferative disorder of the lymphatic system. The drug uses the monoclonal mouse...
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| x Edrecolomab | glycoprotein 17-1A | Colorectal cancer |
Edrecolomab (MAb17-1A, trade name Panorex) is a chimeric mouse/human monoclonal antibody to the cell-surface glycoprotein EpCAM (17-1A), which is expressed on epithelial tissues and on various carcinomas.
Preliminary studies had shown promise of a...
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| x Tositumomab | CD20 | Follicular lymphoma |
Tositumomab is a monoclonal antibody derived from immortalized mouse cells. It is a IgG2a anti-CD20 antibody and is covalently bound to I. I emits both beta and gamma radiation and decays with a half-life of 8 days.
Clinical trials have established...
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| x Cetuximab | Epidermal growth factor receptor | Colorectal cancer |
Cetuximab (IMC-C225 -- marketed under the name Erbitux) is a chimeric (mouse/human) monoclonal antibody, an epidermal growth factor receptor (EGFR) inhibitor, given by intravenous infusion for treatment of metastatic colorectal cancer and head and...
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| x Atorvastatin |
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LDL Cholesterol Reduction |
Atorvastatin (INN) (pronounced /əˌtɔrvəˈstætən/) (Lipitor, Pfizer), is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms....
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| x Fluticasone/salmeterol |
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Chronic bronchitis |
The combination preparation fluticasone/salmeterol is a formulation containing fluticasone propionate and salmeterol xinafoate used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is marketed by GlaxoSmithKline under...
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| Asthma | |||||
| x Esomeprazole |
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Esomeprazole (pronounced /iːsɵˈmɛprəzoʊl/) is a proton pump inhibitor (brand names Sompraz, Zoleri, Nexium®, Lucen, Esopral; Axagon in Italy, Nexiam in Belgium) developed and marketed by AstraZeneca which is used in the treatment of dyspepsia,...
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| x Montelukast |
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Rhinitis |
Montelukast (trade name Singulair)(Openair in Pakistan) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast is a...
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| Asthma | |||||
| x Fluorouracil |
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Bevacizumab | Colorectal cancer |
Fluorouracil (5-FU or f5U) (Adrucil, Efudex, Fluoroplex) is a pyrimidine analog, which is used as a drug in the treatment of cancer. It belongs to the family of drugs called antimetabolites. It is typically administered with leucovorin.
The...
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| x Carboplatin |
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Paclitaxel | Non-Small Cell Lung Carcinoma |
Carboplatin is a chemotherapy drug used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers). It was introduced in the late 1980s and has since gained popularity in clinical treatment due to its vastly reduced side...
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| Bevacizumab | |||||
