Acetazolamide

Acetazolamide, sold under the trade name Diamox, is a carbonic anhydrase inhibitor that is used to treat glaucoma, epileptic seizures, Idiopathic intracranial hypertension (pseudotumor cerebri), altitude sickness, cystinuria, and dural ectasia. Acetazolamide is available as a generic drug and is also a diuretic. Acetazolamide is a carbonic anhydrase inhibitor. Medically it may be used to treat conditions of moderate to severe metabolic or respira... More

Acetazolamide, sold under the trade name Diamox, is a carbonic anhydrase inhibitor that is used to treat glaucoma, epileptic seizures, Idiopathic intracranial hypertension (pseudotumor cerebri), altitude sickness, cystinuria, and dural ectasia. Acetazolamide is available as a generic drug and is also a diuretic. Acetazolamide is a carbonic anhydrase inhibitor. Medically it may be used to treat conditions of moderate to severe metabolic or respiratory alkalosis. It does this by interfering with bicarbonate (HCO3) reabsorption in the kidneys, thereby re-acidifying the blood (and thus alkalinizing the urine). Carbonic anhydrase (CA) catalyzes the first part of the following reversible reaction (the second half happens spontaneously, favouring production of H + HCO3), in which carbon dioxide (CO2) and water (H2O) are converted to carbonic acid (H2CO3) and vice-versa: CO2 + H2O H2CO3 H + HCO3 In the kidney tubules, locally secreted hydrogen ions normally combine with filtered...

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