Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma that features in the World Health Organisation (WHO) classification of lymphomas.
Its name derives from anaplasia and large cell lymphoma.
It occurs in both nodal and extranodal locations. It typically presents at a late stage and is often associated with systemic symptoms ("B symptoms").
Granulomas may be present.
To make this diagnosis under its present system of classifica...
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Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma that features in the World Health Organisation (WHO) classification of lymphomas.
Its name derives from anaplasia and large cell lymphoma.
It occurs in both nodal and extranodal locations. It typically presents at a late stage and is often associated with systemic symptoms ("B symptoms").
Granulomas may be present.
To make this diagnosis under its present system of classification, the WHO the presence of "hallmark" cells and immunopositivity for CD30.
The classification acknowledges as typical, but does not require, immunopositivity for ALK (anaplastic lymphoma kinase) protein. It specifically excludes primary cutaneous T-cell lymphomas and other specific types of anaplastic lymphoma (particularly those of B-cell lineage) with CD30 positivity.
The hallmark cells are of medium size and feature abundant cytoplasm (which may be clear, amphophilic or eosinophilic), kidney shaped nuclei, and a paranuclear eosinophilic...
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