Bullous pemphigoid, also referred to as BP, is an acute or chronic autoimmune skin disease, involving the formation of blisters, more appropriately known as bullae, at the space between the skin layers epidermis and dermis.
Clinically the earliest lesions may appear urticarial (like hives). Tense bullae eventually erupt, most commonly at the inner thighs and upper arms but the trunk and extremities are frequently both involved. Any part of the sk...
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Bullous pemphigoid, also referred to as BP, is an acute or chronic autoimmune skin disease, involving the formation of blisters, more appropriately known as bullae, at the space between the skin layers epidermis and dermis.
Clinically the earliest lesions may appear urticarial (like hives). Tense bullae eventually erupt, most commonly at the inner thighs and upper arms but the trunk and extremities are frequently both involved. Any part of the skin surface can be involved. Milia are more common with epidermolysis bullosa acquisita (EBA), because of the deeper antigenic targets. A more ring-like configuration, with a central depression or centrally collapsed bullae may indicate linear IgA disease. The disease may be acute, but typically will wax and wane.
As opposed to Pemphigus vulgaris, bullae formation on the oral mucosa are extremely rare in bullous pemphigoid.
There are a number of potential causes including Ibuprofen.
The bullae are formed by an immune reaction, initiated by the...
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