Carboplatin

A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carbopla... More
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Indication or disease:

Therapeutics Disease Phase of development Notes
  • Indicated for unresectable, locally advanced, recurrent or metastatic non-squamous, non-small cell lung cancer.
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