Cefuroxime is a second generation parenteral cephalosporin antibiotic. It was discovered by Glaxo (now GlaxoSmithKline) and introduced in 1978 under the brand name Zinacef. It was approved by FDA on Oct 19, 1983, and is available in US under trade name Ceftin. In India it is available as Supacef by GSK. Cefuroxime axetil is an acetoxyetyl ester prodrug of Cefuroxime which is effective orally. GlaxoSmithKline sells the antibiotic in the United Kin...
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Cefuroxime is a second generation parenteral cephalosporin antibiotic. It was discovered by Glaxo (now GlaxoSmithKline) and introduced in 1978 under the brand name Zinacef. It was approved by FDA on Oct 19, 1983, and is available in US under trade name Ceftin. In India it is available as Supacef by GSK. Cefuroxime axetil is an acetoxyetyl ester prodrug of Cefuroxime which is effective orally. GlaxoSmithKline sells the antibiotic in the United Kingdom (and other countries, such as Australia, Turkey, Israel, Bangladesh, Thailand, Hungary and Poland) under the name Zinnat.
As for the other cephalosporins, although as a second-generation it is less susceptible to beta-lactamase and so may have greater activity against Haemophilus influenzae, Neisseria gonorrhoeae and Lyme disease. Unlike other second generation cephalosporins, cefuroxime can cross the blood-brain-barrier.
Cefuroxime is generally well tolerated and side effects are usually transient. Cefuroxime, if ingested after food, is...
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