Choriocarcinoma is a malignant, trophoblastic and aggressive cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs. It belongs to the far end of the spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumors.
Characteristic feature is the identification of intimately related syncytiotrophoblast and cytotrophoblasts without formation of definite placental type villi.
Syncytiotrophobla...
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Choriocarcinoma is a malignant, trophoblastic and aggressive cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs. It belongs to the far end of the spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumors.
Characteristic feature is the identification of intimately related syncytiotrophoblast and cytotrophoblasts without formation of definite placental type villi.
Syncytiotrophoblasts are large cells with bizarre nuclei and an eosinophilic cytoplasm. They often surround the cytotrophoblasts.
Cytotrophoblasts are polyhedral and regular cells. Have a clear/eosinophillic cytoplasm with hyperchromatic nuclei.
Choriocarcinoma of the placenta during pregnancy is preceded by:
Rarely, choriocarcinoma occurs in primary locations other than the placenta; very rarely, it occurs in testicles. Although trophoblastic components are common components of mixed germ cell tumors, pure choriocarcinoma of the adult testis is rare. Pure...
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