Coenzyme A

Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All sequenced genomes encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester, such as acetyl-CoA) as a substrate. It is adapted from cysteamine, pantothenate, and adenosine triphosphate. Coenzyme A is synthesized in a five-s... More

Formula:

  • C21H36N7O16P3S

Active ingredient of formulation:

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Structure (SMILES):

  • O=C(NCCS)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3OP(=O)(O)O

Chemical Compound

Average Molar Mass:

  • 767.535 g/mol
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Award-Winning Work

Awards Won:

Year Award Award Winner Notes/Description
  • 1953
  • "for his discovery of co-enzyme A and its importance for intermediary metabolism"

Nobel Prize in Physiology or Medicine Winners

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Drug ingredient

Active moiety of formulation:

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Active moiety of drug:

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