Cyclosporine

A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells a... more
top ↑

Similar topics in Freebase

  • Thymectomy

    Thymectomy

    A thymectomy is an operation to remove the thymus gland. It usually results in remission of myasthenia gravis with the help of medication including steroids. However, this remission may not be permanent. There are a number of surgical approaches to the removal of the thymus gland: transsternal ...
  • Neostigmine

    Neostigmine

    Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Neostigmine is available under several trade names such as Prostigmin and Vagostigmin. Neostigmine was first synthesized by Aeschlimann and Reinert in 1931. By interfering with the breakdown of acetylcholine,...
  • Corticosteroids

  • Mycophenolate Mofetil

    The morpholinoethyl ester of mycophenolic acid (MPA) with potent immunosuppressive properties. Mycophenolate stops T-cell and B-cell proliferation through selective inhibition of the de novo pathway of purine biosynthesis. In vivo, the active metabolite, MPA, reversibly inhibits inosine 5'...
  • Intravenous immunoglobulin

    Intravenous immune globulin (IVIG) is a blood product administered intravenously. It contains the pooled IgG (immunoglobulin (antibody) G) extracted from the plasma of over one thousand blood donors. IVIG's effects last between 2 weeks and 3 months. It is mainly used as treatment in three major...

These people have edited this topic:

Edit this topic
Edit and Show details

Add or delete facts, download data in JSON or RDF formats, and explore topic metadata.

Freebase Logo
What is Freebase?

Freebase is a huge collection of facts, built by people like you. Freebase connects facts in ways other sites can't, giving you new ways to explore millions of subjects.
You can help improve it!

Freebase Attribution

Freebase data is free for use under the CC-BY license.

Learn more about Freebase licensing and attribution