Desoxypipradrol, also known as 2-diphenylmethylpiperidine (2-DPMP), is psychoactive drug and research chemical of the piperidine chemical class which acts as a long-lasting stimulant via functioning as a norepinephrine-dopamine reuptake inhibitor (NDRI).
Desoxypipradrol is closely related on a structural level to the compounds methylphenidate (Ritalin, Focalin, Concerta) and pipradrol (Meretran), all three of which share a similar pharmacological...
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Desoxypipradrol, also known as 2-diphenylmethylpiperidine (2-DPMP), is psychoactive drug and research chemical of the piperidine chemical class which acts as a long-lasting stimulant via functioning as a norepinephrine-dopamine reuptake inhibitor (NDRI).
Desoxypipradrol is closely related on a structural level to the compounds methylphenidate (Ritalin, Focalin, Concerta) and pipradrol (Meretran), all three of which share a similar pharmacological action. Of these three piperidines, desoxypipradrol has the longest elimination half-life, as it is a highly lipophilic molecule lacking polar functional groups that are typically targeted by metabolic enzymes. Methylphenidate, on the other hand, is a short-acting compound, as it possesses a methyl-ester moiety that is easily cleaved, forming a highly polar acid group, while pipradrol is intermediate in duration, possessing a hydroxyl group which can be conjugated (e.g. with glucuronide) to increase its hydrophilicity and facilitate excretion...
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