Dimenhydrinate (in US marketed under brand names Dramamine, Driminate, Gravol, Gravamin, Vomex, and Vertirosan) is an over-the-counter drug used to prevent nausea and motion sickness. It is marketed in Portugal as Viabom and in Brazil under the brand Dramin. It is most commonly used as pills, although it is also available in liquid form and in suppositories. This last is particularly useful in the case of persistent vomiting.
Chemically, dimenhyd...
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Dimenhydrinate (in US marketed under brand names Dramamine, Driminate, Gravol, Gravamin, Vomex, and Vertirosan) is an over-the-counter drug used to prevent nausea and motion sickness. It is marketed in Portugal as Viabom and in Brazil under the brand Dramin. It is most commonly used as pills, although it is also available in liquid form and in suppositories. This last is particularly useful in the case of persistent vomiting.
Chemically, dimenhydrinate is a salt of two drugs: diphenhydramine, and 8-chlorotheophylline, a chlorinated derivative of theophylline.
The effects of dimenhydrinate are very similar to those of diphenhydramine. The main differences are a lower potency, and a longer latency. 50 mg dimenhydrinate contains 27.2 mg of diphenhydramine, so it is less potent at equal doses. Also, dimenhydrinate must dissociate into diphenhydramine and its counterion in the body before it is active, so it produces effects more slowly than diphenhydramine.
Theophylline was added in order...
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