Edrecolomab

Edrecolomab (MAb17-1A, trade name Panorex) is a chimeric mouse/human monoclonal antibody to the cell-surface glycoprotein EpCAM (17-1A), which is expressed on epithelial tissues and on various carcinomas. Preliminary studies had shown promise of a possible use in patients with stage III colorectal carcinoma (with metastasis to the lymph nodes). However, when put to a phase III study (2,761 patients) it did not provide any benefit when compared to... more

Edrecolomab (MAb17-1A, trade name Panorex) is a chimeric mouse/human monoclonal antibody to the cell-surface glycoprotein EpCAM (17-1A), which is expressed on epithelial tissues and on various carcinomas. Preliminary studies had shown promise of a possible use in patients with stage III colorectal carcinoma (with metastasis to the lymph nodes). However, when put to a phase III study (2,761 patients) it did not provide any benefit when compared to conventional chemotherapeutic agents. No effect has been demonstrated for stage II (locally advanced cancer without spread to the lymph nodes) colon cancer. Edrecolomab was well tolerated in these studies and as such research has now concentrated on whether it can be of any use in other forms of cancer. less