We have already approved over 24,000 symbols;
the vast majority of these are for protein-coding genes, but also
include symbols for pseudogenes, non-coding RNAs,
phenotypes and genomic features (see HGNC Search).
Our current priority is assigning nomenclature to genes submitted to us
from the Human Genome Project. In addition to this, individual new
symbols are requested by scientists, journals (e.g. Genomics, Nature Genetics) and da...
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Authority and Responsibilities
For each known human gene we approve a gene name and symbol (short-form
abbreviation). All approved symbols are stored in the
HGNC
database. Each symbol is unique and we ensure that each gene is only
given one approved gene symbol. It is necessary to provide a unique
symbol for each gene so that we and others can talk about them, it also
facilitates electronic data retrieval from publications. In preference
each symbol maintains parallel construction in different members of a
gene family and can also be used in other species, especially the
mouse.
We have already approved over 24,000 symbols;
the vast majority of these are for protein-coding genes, but also
include symbols for pseudogenes, non-coding RNAs,
phenotypes and genomic features (see HGNC Search).
Our current priority is assigning nomenclature to genes submitted to us
from the Human Genome Project. In addition to this, individual new
symbols are requested by scientists, journals (e.g. Genomics, Nature Genetics) and databases (e.g. Ensembl, Entrez Gene, MGD, RGD and OMIM),
and groups of new symbols by those working on gene families, chromosome
segments or whole chromosomes. In all cases considerable efforts are
made to use a symbol acceptable to workers in the field.
History
Problems of nomenclature in human genetics were recognised as early as the 1960s and in
1979 full guidelines for human gene nomenclature were presented at the Edinburgh Human Genome Meeting (HGM).
Since then we have continued to strike a compromise between the convenience and simplicity required for the
everyday use of human gene nomenclature and the need for adequate definition of the concepts involved.
The committee has grown from a single force (Dr Phyllis J. McAlpine) to a
team of post-docs and bioinformaticians. For eleven years, from 1996-2007,
the HGNC was chaired by Professor Sue Povey and based at University
College London (UCL). In September 2007 the HGNC relocated to the European
Bioinformatics Institute (EBI), to join the
PANDA (Protein and Nucleotide
Database) group. We regularly attend international meetings such as
American Society of Human Genetics (ASHG) and Human Genome Meeting (HGM),
and sometimes hold workshops in conjunction with these. This ensures that
we are approving gene names in line with the needs of the scientific
community, see previous workshops.
Organisation
We are a non-profit making body which is jointly funded by the US
National Human Genome Research Institute (NHGRI) and the Wellcome Trust
(UK). We operate under the auspices of HUGO, with key policy advice from an International Advisory Committee (IAC). We also use a team of specialist advisors who provide support on specific gene family nomenclature issues, and work in close collaboration with staff at MGNC.
Confidentiality
All enquiries are handled confidentially and unpublished information is never disclosed without explicit permission from the submitters.
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