Ketoconazole (pronounced /ˌkiːtəʊˈkoʊnəzol/) is a synthetic antifungal drug used to prevent and treat skin and fungal infections, especially in immunocompromised patients such as those with AIDS. Ketoconazole is sold commercially as an anti-dandruff shampoo, under brand names Perkhotal by Gepach International, and Nizoral, by Johnson & Johnson.
Ketoconazole is very lipophilic, which leads to accumulation in fatty tissues. The less toxic and more ...
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Ketoconazole (pronounced /ˌkiːtəʊˈkoʊnəzol/) is a synthetic antifungal drug used to prevent and treat skin and fungal infections, especially in immunocompromised patients such as those with AIDS. Ketoconazole is sold commercially as an anti-dandruff shampoo, under brand names Perkhotal by Gepach International, and Nizoral, by Johnson & Johnson.
Ketoconazole is very lipophilic, which leads to accumulation in fatty tissues. The less toxic and more effective triazole compounds fluconazole and itraconazole have largely replaced ketoconazole for internal use. Ketoconazole is best absorbed at highly acidic levels, so antacids or other causes of decreased stomach acid levels will lower the drug's absorption when taken orally.
Ketoconazole was discovered in 1976 and released in 1981. It followed griseofulvin as one of the first available oral treatments for fungal infections.
Ketoconazole is usually prescribed for topical infections such as athlete's foot, ringworm, candidiasis (yeast...
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