An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
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Mitoxantrone
Medicine
Pharmacological class:
Pregnancy category:
Marketed formulations:
- Mitoxantrone hydrochloride 2 injectable solution
- Mitoxantrone hydrochloride 2 injectable concentrate solution
Active moieties:
Active moiety of formulation:
- Mitoxantrone hydrochloride 2 injectable solution
- Mitoxantrone hydrochloride 2 injectable concentrate solution
More specific ingredient:
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