Moexipril

Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) which is used for the treatment of hypertension and congestive heart failure. Moexipril can be administered alone or together with other antihypertensives or diuretics. It works by inhibiting the conversion of angiotensin I to angiotensin II. Moexipril is available from Schwarz'Pharma under the trade name Univasc . Moexipril is available... More

Moexipril hydrochloride is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) which is used for the treatment of hypertension and congestive heart failure. Moexipril can be administered alone or together with other antihypertensives or diuretics. It works by inhibiting the conversion of angiotensin I to angiotensin II. Moexipril is available from Schwarz'Pharma under the trade name Univasc . Moexipril is available as a prodrug moexipril hydrochloride, and is metabolized in the liver to form the pharmacologically active compound moexiprilat. Formation of the active ingredient, moexiprilat, is caused by hydrolysis of an ethyl ester group . Moexipril is incompletely absorbed after oral administration, and its bioavailability is low . The long pharmacokinetic half-life and persistent ACE inhibition of moexipril allows once-daily administration. Moexipril is highly lipophilic , and is in the same hydrophobic range as quinapril, benazepril, and ramipril ....

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