N-Phenethyl-4-piperidone (NPP) is a derivative of 4-piperidone with the molecular formula C13H17NO. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs such as fentanyl.
Because of its possible use in the illicit manufacture of fentanyl, NPP was placed onto the list of controlled chemicals in the USA in 2007, and possession and sales of this compound are now restricted.
The synthesis of N-Phenethyl-4-p...
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N-Phenethyl-4-piperidone (NPP) is a derivative of 4-piperidone with the molecular formula C13H17NO. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs such as fentanyl.
Because of its possible use in the illicit manufacture of fentanyl, NPP was placed onto the list of controlled chemicals in the USA in 2007, and possession and sales of this compound are now restricted.
The synthesis of N-Phenethyl-4-piperidone cannot be prepared via the simple SN2 substitution reaction reported on the web using 4-piperidone with phenethyl bromide in the presence of a phase transfer catalyst. It's preparation requires sophisticated laboratory equipment and considerable knowledge and skill with organic chemistry. It is made by the Claisen condensation of ethyl acrylate with 2 phenylethylamine.
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N-Phenethyl-4-piperidone is useful in the synthesis of pharmaceuticals, primarily fentanyl and its analogs. Paul Janssen...
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