Omapatrilat (INN) is a novel antihypertensive agent that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE). NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling.
This drug from Bristol-Myers Squibb was not approved by the U.S. Food and Drug Administration due to angioedema safety concerns.
Read article at Wikipedia
Omapatrilat
We can tell you that Omapatrilat is a
If you know more about Omapatrilat, you can add more facts here »
Similar topics in Freebase
-
Carboplatin
Carboplatin is a chemotherapy drug used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers). It was introduced in the late 1980s and has since gained popularity in clinical treatment due to its vastly reduced side-effects compared to its parent compound cisplatin.... -
Salvinorin A
Salvinorin A is the main active psychotropic molecule in Salvia divinorum, a Mexican plant which has a long history of use as an entheogen by indigenous Mazatec shamans. Salvinorin A is a hallucinogenic compound with dissociative effects. It is structurally distinct from other naturally-occurring... -
Estramustine
Estramustine (Emcyt) is a chemotherapy agent used to treat prostate cancer. It is a derivative of estrogen (specifically, estradiol) with an nitrogen mustard-carbamate ester moiety that makes it a alkylating antineoplastic agent similar to mechlorethamine, with estrogen-induced specificity.... -
ACE inhibitor
ACE inhibitors, or inhibitors of angiotensin-converting enzyme (ACE), are a group of pharmaceuticals that are used primarily in treatment of hypertension and congestive heart failure, in some cases as the drugs of first choice. This system is activated in response to hypotension, decreased sodium... -
Bromopride
Bromopride (INN) is a dopamine antagonist with prokinetic properties widely used as an antiemetic, closely related to metoclopramide. It is not available in the United States. Bromopride appears to be safe and effective for use in pregnancy. Bromopride is indicated in the treatment of nausea and... -
Flumedroxone
Flumedroxone is a corticosteroid derivative used to treat migraines. -
CP-751,871
-
Cyclizine
Cyclizine is an antihistamine drug used to treat nausea, vomiting and dizziness associated with motion sickness, vertigo and post-operative following administration of general anaesthesia and opioids. It's also considered the gold standard of opiate/opioid-enhancing anti-histamine boosters.... -
Pirolazamide
Pirolazamide is an antidepressant drug. -
Cefoxitin
Cefoxitin is a cephamycin antibiotic developed by Merck & Co., Inc., often grouped with the second−generation cephalosporins. It is also known as Mefoxin. Cefoxitin acts by interfering with cell wall synthesis. Its activity spectrum includes a broad range of gram-negative and gram-positive bacteria...
You can help improve this topic by adding more facts here