Reversible Inhibition of Sperm Under Guidance (RISUG), formerly referred to as SMA, is the development name of a male contraceptive developed at IIT Delhi in India by Dr. Sujoy K Guha. It is currently undergoing Phase III clinical trials in India. It has been patented in India, China, Bangladesh and the United States.
RISUG works by an injection into the vas deferens, the vessel through which the sperm moves before ejaculation. In a matter of min...
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Reversible Inhibition of Sperm Under Guidance (RISUG), formerly referred to as SMA, is the development name of a male contraceptive developed at IIT Delhi in India by Dr. Sujoy K Guha. It is currently undergoing Phase III clinical trials in India. It has been patented in India, China, Bangladesh and the United States.
RISUG works by an injection into the vas deferens, the vessel through which the sperm moves before ejaculation. In a matter of minutes, the injection coats the walls of the vas with a clear gel made of 60 mg of the copolymer styrene/maleic anhydride (SMA) with 120 µL of the solvent dimethyl sulfoxide. The copolymer is made by irradiation of the two monomers with a dose of 0.2 to 0.24 megarad for every 40 g of copolymer and a dose rate of 30 to 40 rad/s. The source of irradiation is cobalt-60 gamma radiation.
The effect the chemical has on sperm is not completely understood. Originally it was thought that it lowered the pH of the environment enough to kill the sperm. More...
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