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Rituximab
Rituximab, sold under the trade names Rituxan and MabThera, is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of B cells. Rituximab is used in the treatment of many lymphomas, leukemias, and some autoimmune disorders.
Rituximab was developed by IDEC...
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Rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks the joints producing an inflammatory synovitis that often progresses to destruction of the articular cartilage...
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Non-Hodgkin lymphoma
Distinct from Hodgkin lymphoma both morphologically and biologically, Non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy...
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B-cell lymphoma
The B-cell lymphomas are types of non-Hodgkin lymphoma affecting B cells. It develops more frequently in immunocompromised individuals (such as those with AIDS.)
There are fourteen kinds of lymphomas involving B cells.
Five account for nearly three...
Phase of development:
Systemic lupus erythematosus
Systemic lupus erythematosus (SLE or lupus, pronounced sɪˈstɛmɪk ˈluːpəs ˌɛrəˌθiməˈtoʊsəs (help·info)) is a chronic autoimmune connective tissue disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system...
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ANCA-associated vasculitides
ANCA-associated vasculitides (AAV) are diseases caused by vasculitis in which antineutrophil cytoplasmic antibodies (ANCAs) can be detected in the blood.
Three AAVs are Churg-Strauss syndrome, microscopic polyangiitis and Wegener's granulomatosis....
Phase of development:
Multiple sclerosis
Multiple sclerosis (abbreviated MS, also known as disseminated sclerosis or encephalomyelitis disseminata) is an idiopathic disease of suspected autoimmune cause, in which the body's immune response attacks a person's central nervous system (brain...
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Lupus nephritis
Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease of the immune system. Apart from the kidneys, SLE can also damage the skin, joints, nervous system and virtually any organ or system in the body...
Phase of development:
Chronic lymphocytic leukemia
B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most common type of leukemia. Leukemias are abnormal and malignant neoplastic proliferations ("cancers") of the white blood cells (leukocytes). CLL...
