Sickle-cell disease

Sickle-cell disease, or sickle-cell anaemia (or drepanocytosis), is a life-long blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various complications. The sickling occurs because of a mutation in the hemoglobin gene. Life expectancy is shortened, with studies reporting an average life expectancy of 42 and 48 years for males and females... more

Also known as:

  • sickle-cell anaemia,
  • drepanocytosis,
  • haemoglobin S,
  • SS disease,
  • HbSS
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