Splice

Splice is a science fiction film directed by Vincenzo Natali and starring Adrien Brody and Sarah Polley, who portray two young scientists who begin involving human DNA in their splicing of animal genes. Two young scientists (Brody and Polley) achieve fame by splicing human DNA with the DNA of different animals to create a new creature. In the process they ignore their society's ethical and legal boundaries. The scientists name their creature "Dr... more

Splice is a science fiction film directed by Vincenzo Natali and starring Adrien Brody and Sarah Polley, who portray two young scientists who begin involving human DNA in their splicing of animal genes. Two young scientists (Brody and Polley) achieve fame by splicing human DNA with the DNA of different animals to create a new creature. In the process they ignore their society's ethical and legal boundaries. The scientists name their creature "Dren", which is initially a deformed female infant, however, rapidly develops into a beautiful but deadly winged human-chimera. Splice was written by director Vincenzo Natali and screenwriters Doug Taylor and Antoinette Terry Bryant. The script was originally meant to follow up Natali's Cube (1997), but the budget and restricted technology hindered the project. In 2007, the project entered active development as a 75% Canadian and 25% French co-production, receiving a budget of $26 million. The director described the film: "Splice is very much... less