The term "transgenic mice" refers to genetically modified animals of the genus and species Mus musculus. Strinctly speaking there are two proper uses of the term "transgenic." The strictest meaning is an organism with an added gene. This is most often in practice an artificial gene that contains three major components; 1) a protein or RNA coding sequence, 2) promoter sequences that direct its expression to the proper tissue, cell type and develop...
more
The term "transgenic mice" refers to genetically modified animals of the genus and species Mus musculus. Strinctly speaking there are two proper uses of the term "transgenic." The strictest meaning is an organism with an added gene. This is most often in practice an artificial gene that contains three major components; 1) a protein or RNA coding sequence, 2) promoter sequences that direct its expression to the proper tissue, cell type and developmental stage, and 3) other regulatory sequences to properly direct expression and post-transcriptional regulation of the trangene, including splicing and polyadenylation. The second usage refers more generally to any genetically modified animal and is used frequently in the sciences to mean either an animal with an artificial gene insertion, OR and animal created by modifying the genome via homologous recombination (see gene targeting by homologous recombination in embryonic stem cells). Transgenic organisms have been engineered in plants and...
less
