Triclocarban (TCC), or 3,4,4'-trichlorocarbanilide, is a substance with anti-bacterial and anti-fungal properties that is used in disinfectants, soaps and other household products.
The mechanism of action involves disruption of cellular membranes, and the chemical may also involve inhibition of the enzyme enoyl-acyl carrier protein reductase (ENR). This enzyme is absent in humans but is essential in building cell membranes of many bacteria and fu...
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Triclocarban (TCC), or 3,4,4'-trichlorocarbanilide, is a substance with anti-bacterial and anti-fungal properties that is used in disinfectants, soaps and other household products.
The mechanism of action involves disruption of cellular membranes, and the chemical may also involve inhibition of the enzyme enoyl-acyl carrier protein reductase (ENR). This enzyme is absent in humans but is essential in building cell membranes of many bacteria and fungi.
Researchers at UC Davis have reported that Triclocarban can act as an endocrine disruptor. While TCC shows little or no endocrine activity by itself, it was found to enhance the biological activity of the endogenous hormone testosterone by in vitro cell-based bioassay as well as in vivo in a male rat model. Testosterone normally mediates transcriptional activity in sexual reproductive organs, but TCC appears to significantly amplify this activity. Ten day oral exposure to TCC caused a substantial increase in the weight of accessory sexual...
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