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Zidovudine
Zidovudine (INN) or azidothymidine (AZT) (also called ZDV) is a nucleoside analog reverse transcriptase inhibitor (NRTI), a type of antiretroviral drug. It was the first approved treatment for HIV. It is also sold under the names Retrovir and Retrovis, and as an ingredient in Combivir and Trizivir....
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A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)
The study is designed to test the drug zidovudine (AZT) in children, including study of drug levels in various parts of the body fluids, safety of the drug, and its effect on different parts of the body. The effects of any drug, the way a drug enters...
- x ClinicalTrials.gov Identifier:
- NCT00000701
- x Type of trial:
- Interventional
Methadone Effects on Zidovudine (ZDV, AZT) Disposition
To determine whether methadone maintenance alters the pharmacokinetics of zidovudine (AZT). To determine whether any such effect of methadone on disposition of AZT is time dependent and whether a metabolic interaction between AZT and methadone...
- x ClinicalTrials.gov Identifier:
- NCT00000800
- x Type of trial:
- Interventional
A Multi-Center Clinical Trial to Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients with AIDS Post First Episode PCP
To examine the dose of zidovudine (AZT) that was used in the first placebo-controlled study of AZT in AIDS patients as well as a lower dose of AZT in order to determine if the lower dose results in less harmful side effects while still being...
- x ClinicalTrials.gov Identifier:
- NCT00000700
- x Type of trial:
- Interventional
A Study of Zidovudine in HIV-Infected Patients With Liver Disease
To examine the pharmacokinetics (blood levels) and bioavailability of zidovudine (AZT) given to patients with HIV infection and chronic liver disease. The specific aim of the study is to provide data permitting the development of guidelines for use...
- x ClinicalTrials.gov Identifier:
- NCT00001001
- x Type of trial:
- Interventional
