/guid/9202a8c04000641f8000000006bca603 rename

AFPep (Alpha Fetoprotein Peptide) is an orally active cyclic peptide with molecular weight of 969...

AFPep (Alpha Fetoprotein Peptide) is an orally active cyclic peptide with molecular weight of 969 Daltons and is derived from the anti-oncogenic active site (residues 472-479) of alpha fetoprotein (AFP). Using the standard amino acid abbreviations, AFPep has the sequence cyclo-(EKTOVNOGN), where O is hydroxyproline. This peptide has been shown in experimental animal models to be efficacious in the prevention and treatment of ER+ breast cancer. Multiple births by a woman are strongly associated with a lower risk of developing breast cancer later in her life. One of the contributing factors for this association appears to be α-fetoprotein (AFP) produced by the fetal liver which crosses the placenta and enters into the maternal circulation. Pregnancy-associated protection from breast cancer is directly proportional to exposure level to AFP. Furthermore it has been demonstrated that tumor growth can be inhibited by AFP in animal models of breast cancer. It is speculated that AFP may induce apoptosis in pre-malignant breast tissue cells which would have later developed into malignancies. Through mimicking the effects of AFP, AFPep inhibits the proliferation of estrogen receptor-positive