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x Evaluation of Neuromuscular Disease   NCT00001201 National Institute of Neurological Disorders and Stroke Observational
The peripheral nervous system is the portion of the nervous system outside of the brain and spinal cord. It includes the 12 pairs of cranial nerves, 31 pairs of spinal nerves and their branches, nerves responsible for sensation and maintenance of...
x Pharmacological Modulation of Cocaine Effects – 1   NCT00000201 National Institute on Drug Abuse Interventional
The purpose of this study is to conduct human laboratory studies of possible cocaine interactions with various potential treatment medications.
Johns Hopkins University
x Feasibility Study of Take-Home LAAM Medication – 3   NCT00000300 National Institute on Drug Abuse Interventional
The purpose of this study is to test therapeutic benefits of take-home LAAM. (1) Do subjects with take-home LAAM availability show increased clinical responsibility over subjects without; (2) Do subjects with take-home LAAM attempt diversion when...
x Cocaine Effects in Humans: Physiology and Behavior – 1   NCT00000200 National Institute on Drug Abuse Interventional
The purpose of this study is to compare the effects of buprenorphine or methadone maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving, in opiate-dependent cocaine users.
Columbia University
x Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence – 4   NCT00000301 National Institute on Drug Abuse  
The purpose of this study is to empirically test a series of medications to: 1) determine each medication's efficacy in treatment of cocaine abuse/dependence; 2) find most effective dose range for each medication. In this study, amantadine is tested...
x Alendronate and/or Parathyroid Hormone for Osteoporosis   NCT00000400 National Institute of Arthritis and Musculoskeletal and Skin Diseases Interventional
This study looks at the effects of two medications, alendronate and parathyroid hormone, on bone mass and on bone formation and bone breakdown in women with osteoporosis. We will randomly select postmenopausal women who have osteoporosis to receive...
x Oral Collagen for Rheumatoid Arthritis Rheumatoid arthritis joint NCT00000401 National Institute of Arthritis and Musculoskeletal and Skin Diseases Interventional
Rheumatoid arthritis (RA) is an autoimmune disease characterized by swelling and inflammation of the joints. In RA, the immune system attacks a person's own cells inside joints, eventually leading to joint damage and disability. This study will...
x Hypertension Prevention Trial (HPT) Feasibility Study   NCT00000501 National Heart, Lung, and Blood Institute Interventional
To test the feasibility and the efficacy of nutritional interventions in the primary prevention of hypertension in individuals predisposed to the development of hypertension; specifically, to test the hypothesis that reduction of weight and/or...
x Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-up   NCT00000600 National Heart, Lung, and Blood Institute Interventional
This study will evaluate the effects of vitamin E supplementation in retarding the progression of common carotid artery intima-media thickening in African Americans.   BACKGROUND: Evidence from epidemiologic studies, and from one unpublished study...
x Postmenopausal Hormone Therapy in Unstable Angina   NCT00000601 National Heart, Lung, and Blood Institute Interventional
To determine if estrogen therapy in postmenopausal women with unstable angina reduces the incidence of ischemic episodes.   BACKGROUND: Unstable angina is a frequent diagnosis in post-menopausal women and is associated with a significant risk of...
x A Phase I Evaluation of Azidothymidine (AZT) in Children with Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)   NCT00000701 National Institute of Allergy and Infectious Diseases Interventional
The study is designed to test the drug zidovudine (AZT) in children, including study of drug levels in various parts of the body fluids, safety of the drug, and its effect on different parts of the body. The effects of any drug, the way a drug enters...
x Physicians' Health Study   NCT00000500 National Heart, Lung, and Blood Institute Interventional
To assess the effect on cardiovascular mortality of alternate-day consumption of 325 milligrams of aspirin and, secondarily, the effect on cancer incidence of alternate-day consumption of 50 milligrams of beta-carotene. BACKGROUND: Thrombosis plays a...
x Methadone Effects on Zidovudine (ZDV, AZT) Disposition   NCT00000800 National Institute of Allergy and Infectious Diseases Interventional
To determine whether methadone maintenance alters the pharmacokinetics of zidovudine (AZT). To determine whether any such effect of methadone on disposition of AZT is time dependent and whether a metabolic interaction between AZT and methadone...
GlaxoWellcome
x The Effects of Illnesses on HIV Levels in the Body   NCT00000900 National Institute of Allergy and Infectious Diseases Observational
To describe the magnitude and duration of changes in HIV-1 RNA levels during and after an acute febrile illness. To identify factors associated with increases, i.e., type of illness ultimately diagnosed (bacterial, viral, fungal), CD4 cell count,...
x A Multi-Center Clinical Trial to Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients with AIDS Post First Episode PCP   NCT00000700 National Institute of Allergy and Infectious Diseases Interventional
To examine the dose of zidovudine (AZT) that was used in the first placebo-controlled study of AZT in AIDS patients as well as a lower dose of AZT in order to determine if the lower dose results in less harmful side effects while still being...
x Phase II Trial of Sequential Chemotherapy and Radiotherapy for AIDS- Related Primary Central Nervous System Lymphoma   NCT00000801 National Institute of Allergy and Infectious Diseases Interventional
To estimate the response rate, overall and disease-free survival, toxicities, factors associated with outcome, and effect on quality of life in patients with AIDS-related primary CNS lymphoma treated with CHOD (cyclophosphamide, doxorubicin,...
x Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children   NCT00000901 National Institute of Allergy and Infectious Diseases Interventional
The purpose of this study is to see if it is safe and effective to give an anti-HIV drug combination of indinavir (IDV) plus stavudine (d4T) plus lamivudine (3TC) to HIV-infected children. IDV will be given either as a powder mixed into applesauce...
x A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection   NCT00001000 National Institute of Allergy and Infectious Diseases Interventional
To evaluate the degree and sequence of immunologic enhancement and the cellular resistance to certain infections after a single dose of atvogen (ampligen). In addition, the relationship between activation of immune cells and biochemical markers of...
x A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital Cytomegalovirus (CMV) Infections.   NCT00001100 National Institute of Allergy and Infectious Diseases Interventional
The purpose of this study is to evaluate the benefits and safety of the antiviral drug ganciclovir (DHPG) given intravenously to treat newborn infants who are born infected with cytomegalovirus (CMV). CMV is a herpes virus that can infect most...
x A Study of Zidovudine in HIV-Infected Patients With Liver Disease   NCT00001001 National Institute of Allergy and Infectious Diseases Interventional
To examine the pharmacokinetics (blood levels) and bioavailability of zidovudine (AZT) given to patients with HIV infection and chronic liver disease. The specific aim of the study is to provide data permitting the development of guidelines for use...
x Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections   NCT00001658 National Institute of Mental Health Interventional
Bacteria carry substances on their surface called antigens. When antigens come into contact with the right kinds of cells in the body an immune reaction is caused. This reaction is often the symptoms of sickness that a patient feels. In order for the...
x Efficacy and Safety of SPD417 in Treatment of Manic Symptoms in Adults With Bipolar I Disorder   NCT00150553 Validus Pharmaceuticals Interventional
The purpose of this study is to compare the efficacy and safety of SPD417 in treating bipolar manic symptoms, when given once daily in the evening vs. twice daily.
x Memantine in Systemic Lupus Erythematosus   NCT00181298 Forest Laboratories, Inc. Interventional
Neuropsychiatric manifestations of Systemic Lupus Erythematosus (NPSLE) are both common and an important source of morbidity. Of the case definitions for NPSLE syndromes that have recently been developed, cognitive dysfunction appears to be the most...
Johns Hopkins University
x The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome   NCT00215800 Hemispherx BioPharma, Inc. Interventional
Multi-center, double-blind, randomized, placebo-controlled study of the safety and efficacy.
x Valganciclovir (Valcyte) for Chronic Fatigue Syndrome Patients Who Have Elevated Antibody Titers Against Human Herpes Virus 6 (HHV-6)and Epstein-Barr Virus (EBV)   NCT00478465 Stanford University Interventional
The purpose of this study determine whether the drug valganciclovir has a significant and real benefit on the central core of symptoms experienced by patients who have high titers to EBV and HHV-6 and are experiencing long-standing fatigue and...
x Role of Antibodies in Cognitive Dysfunction in Patients With Systemic Lupus Erythematosus   NCT00042523 National Institute of Arthritis and Musculoskeletal and Skin Diseases Observational
This study will examine the possible relationship between certain antibodies found in patients with systemic lupus erythematosus (SLE) and cognitive (thought processing) impairment in these patients. Antibodies are proteins produced by cells of the...
x Behavioral Insomnia Therapy With Chronic Fatigue Syndrome   NCT00540254 National Institute of Nursing Research Interventional  
x Study of Teriparatide (FORTEO) to Treat Adults With Osteogenesis Imperfecta (OI)   NCT00131469 National Institutes of Health    
Osteogenesis Imperfecta Foundation
Eli Lilly and Company
Oregon Health & Science University
x stage 2          
x Pfizer Pfizer      
Pfizer Incorporated (NYSE: PFE) is a pharmaceutical company, ranking number one in sales in the world. The company is based in New York City, with its research headquarters in Groton, Connecticut. It produces Lipitor (atorvastatin, used to lower...
x Nimotuzumab in Adults With Glioblastoma Multiforma   NCT00753246 Oncosciences AG Interventional
From http://clinicaltrials.gov  "The objective of the present study is a comparison of treatment of patients with newly diagnosed glioblastoma multiforme grade IV. Patients will be randomized in one of two arms when included. Patients randomly...
x Nimotuzumab in advanced head and neck tumors in combination with radiotherapy and radiochemotherapy          
x Nimotuzumab in recurrent or relapsed children high grade gliomas          
x Nimotuzumab in Adults With Anaplastic Astrocytomas and Glioblastoma Multiforme          
x Rosacea Clinical Study          
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