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10,311 NCI Term topics matching:
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| x name | x image | x URI | x article |
| x Insulin Receptor Substrate 1 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Insulin_Receptor_Substrate-1 |
The protein IRS1 acts as an interface between signaling proteins with Src homology-2 domains (SH2 proteins) and the receptors for insulin, IGF2, growth hormone, several interleukins (IL4, IL9, IL13), and other cytokines. It regulates gene expression...
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| x Cellular Infiltration | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Cellular_Infiltration |
Normal or pathologic migration and accumulation of cells within tissues.
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| x IFN Alpha Signaling Pathway | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#IFN_Alpha_Signaling_Pathway |
Interferon alpha plays a role in viral infections. Signaling takes place through an IFN receptor complex consisting of two alpha chains (type I receptor) complexed with Jak1 and Tyk2. These kinases phosphorylate Stat1 and Stat2 respectively. ...
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| x Globo H-GM2-Lewis-y-MUC1-32-mer-TF(c)-Tn(c)-KLH Conjugate Vaccine/QS21 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Globo-H-GM2-Lewis-y-MUC1-32-mer-TF_c_Tn_c_KLH-Conjugate-Vaccine_QS21 |
A multivalent vaccine comprised of Globo H (Globo H Hexasaccharide 1), GM2, Lewis-y, MUC1-32-mer, TF(c), and Tn(c) antigens conjugated with Keyhole Limpet Hemocyanin, an immunomodulator, plus QS21, an immune enhancer. (NCI)
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| x Nitric Oxide Synthetase | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Nitric_Oxide_Synthetase |
Expressed in various cell types, Nitric Oxide Synthases (NOS Family) are constitutive or inducible calcium/calmodulin stimulated homodimers stabilized by BH4 that bind FAD and FMN cofactors, generally contain a flavodoxin-like domain, and synthesize...
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| x Xq11.2-q12 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Xq11_2-q12 |
A chromosome band present on Xq
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| x Chromosome Segregation | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Chromosome_Segregation |
The separation of chromosomes into daughter cells during cell division. (GO)
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| x Neurotrophic Tyrosine Kinase Receptor Type 1 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Neurotrophic_Tyrosine_Kinase_Receptor_Type-1 |
Human NTRK1 Gene (TKRI/INSR Family) encodes neuronal TRKA-I and non-neural TRKA-II isoforms (similar biological properties) of type I membrane protein Neurotrophic Tyrosine Kinase Receptor Type 1, containing 2 LRR repeats and 2 Ig-like C2-type...
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| x Xq22.2 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Xq22_2 |
A chromosome band present on Xq
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| x 14q13.2 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_14q13_2 |
A chromosome band present on 14q
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| x Neuromedin B Receptor | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Neuromedin-B_Receptor |
A mammalian homolog of amphibian bombesin, Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue. (from OMIM)
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| x NMYC Interactor | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#NMYC_Interactor |
NMYC interactor (NMI) is a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and...
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| x Ethylchlorformate Vaccine | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Ethylchlorformate_Vaccine |
A tumor vaccine comprised of ethylchlorformate polymerized tumor protein, obtained by treating tumor cells with ethylchloroformate to produce a tumor-specific immunotherapeutic agent. (NCI)
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| x 6q14.3 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_6q14_3 |
A chromosome band present on 6q
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| x 15q26.3 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_15q26_3 |
A chromosome band present on 15q
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| x Hypercholesterolemia | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Hypercholesterolemia |
Hypercholesterolemia; the presence of an abnormal amount of cholesterol in the cells and plasma of the blood.
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| x 12p13-p12 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_12p13-p12 |
A chromosome band present on 12p
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| x Transcription Termination | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Transcription_Termination |
Transcription Termination is the cessation of cellular activities involved in the synthesis a nascent RNA transcript.
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| x 9p24.1 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_9p24_1 |
A chromosome band present on 9p
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| x Signal Transducer and Activator of Transcription 4 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Signal_Transducer_and_Activator_of_Transcription-4 |
This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the...
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| x Placental Growth Factor | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Placental_Growth_Factor |
Placental Growth Factor, encoded by the PGF gene, belongs to the PDGF/VEGF growth factor family. Placental Growth Factor is active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. Three isoforms exist from...
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| x Signal Transducer and Activator of Transcription 5A | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Signal_Transducer_and_Activator_of_Transcription-5A |
This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the...
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| x Signal Transducer and Activator of Transcription 6 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Signal_Transducer_and_Activator_of_Transcription-6 |
This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the...
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| x Activator of S Phase Kinase | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Activator_of_S_Phase_Kinase |
The G1/S transition in eukaryotic cells is strictly regulated so that DNA replication occurs only once during S phase. The CDC7L1 kinase complex may trigger S phase by directly activating the replication initiation complexes assembled at the origins...
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| x CDC7 Cell Division Cycle 7 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#CDC7_Cell_Division_Cycle-7_Protein |
CDC7 Cell Division Cycle 7, encoded by the CDC7 gene, is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. Although expression levels of this protein appear constant throughout the cell cycle, the...
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| x Baculoviral IAP Repeat-Containing Protein 6 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Baculoviral_IAP_Repeat-Containing_Protein-6 |
Baculoviral IAP Repeat-Containing Protein 6, encoded by the BIRC6 gene, is a member of the IAP (inhibitors of apoptosis proteins) family and the ubiquitin-conjugating enzyme family. This protein is expressed as a 530-kD protein in gliomas and...
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| x 19q13.13 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_19q13_13 |
A chromosome band present on 19q
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| x 9p12 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_9p12 |
A chromosome band present on 9p
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| x Orthologous Gene | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Orthologous_Gene |
A gene from one species which corresponds to a gene in another species that is related via a common ancestral species (a homologous gene), but which has evolved to become different from the gene of the other species.http://biotech.icmb.utexas.edu
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| x Transcription Factor-Like Nuclear Regulator | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Transcription_Factor-Like_Nuclear_Regulator |
Encoded by widely expressed human BDP1 Gene, 2254-aa 253-kD highly hydrophilic Transcription Factor-Like Nuclear Regulator contains several potential phosphorylation sites, two bipartite NLS, a DNA-ligase A1 ATP-dependent binding site, a MYB-like...
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| x Brain-Specific Angiogenesis Inhibitor 2 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Brain-Specific_Angiogenesis_Inhibitor-2 |
Encoded by human BAI2 Gene (GPCR2 Family), similar to BAI1, and expressed in brain, heart, thymus, and skeletal muscle, 1572-aa 171-kD (precursor) Brain-Specific Angiogenesis Inhibitor 2, a seven-span transmembrane protein containing a GPS and 4 TSP...
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| x Small Inducible Cytokine A13 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Small_Inducible_Cytokine-A13 |
Induced by IL-1 and TNF-alpha, widely expressed, and encoded by human CCL13 Gene (Intercrine Beta Family), 98-aa 11-kD (precursor) Small Inducible Cytokine A13 is a secreted chemotactic factor for monocytes, lymphocytes, basophils, and eosinophils...
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| x Small Inducible Cytokine A3-Like 1 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Small_Inducible_Cytokine-A3-Like-1_Protein |
Encoded by human CCL3L1 Gene (Intercrine Beta Family), secreted 93-aa 10-kD (precursor) Small Inducible Cytokine A3 Like 1 is a putative chemokine involved in immunoregulatory and inflammatory processes. (NCI)
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| x Small Inducible Cytokine A18 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Small_Inducible_Cytokine-A18 |
Induced by glucocorticoids, PMA, IL-4, IL-13, and IL-10 and expressed by human CCL18 Gene (Intercrine Beta Family) in lung, lymph nodes, placenta, bone marrow, dendritic cells, and macrophages, secreted 89-aa 10-kDa (precursor) Small Inducible...
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| x Small Inducible Cytokine A22 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Small_Inducible_Cytokine-A22 |
Expressed in macrophage, monocyte-derived dendritic cells, thymus, lymph node, appendix, activated monocytes, resting and activated macrophages, lung, small intestine, and spleen by human CCL22 Gene (Intercrine Beta Family), secreted...
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| x Small Inducible Cytokine A25 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Small_Inducible_Cytokine-A25 |
Expressed in thymic and intestinal dendritic cells by CCL25 Gene (Intercrine Beta Family), secreted immunoregulatory 150-aa 17-kD (precursor) Small Inducible Cytokine A25 is a CCR9 receptor agonist and chemotactic for thymocytes, activated...
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| x Punch Biopsy | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Punch_Biopsy |
Removal of a disk of skin tissue, for microscopic examination, using a punch.
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| x Tracheobronchial | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Tracheobronchial |
Pertaining both to the tracheal and bronchial tubes, or to their junction.
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| x Enhancing Lesion | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Enhancing_Lesion |
An enhancing lesion is a well-demarcated area of unequivocally increased signal intensity on T1-weighted spin-echo (SE) images compared with normal-appearing, surrounding tissue following intravenous injection of a gadolinium chelate.from http://cni...
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| x Reader | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Reader |
The specific medical individual, usually a radiologist, who looks at and interprets a medical image.
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| x 10p12.1 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_10p12_1 |
A chromosome band present on 10p
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| x Innate Bone Remodeling | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Innate_Bone_Remodeling |
Innate Bone Remodeling takes place in the adult skeleton at discrete foci. The continuous turnover of bone matrix and mineral that involves first, an increase in bone resorption (osteoclastic activity) and later, reactive bone formation ...
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| x Small Inducible Cytokine B10 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Small_Inducible_Cytokine-B10 |
Encoded by Interferon Gamma-induced human CXCL10 Gene (Intercrine Alpha/Chemokine CXC Family), secreted 98-aa 11-kD (precursor) Small Inducible Cytokine B10 is a chemotactic chemokine ligand for receptor CXCR3 that causes stimulation of monocyte,...
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| x Small Inducible Cytokine B11 | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Small_Inducible_Cytokine-B11 |
Encoded by INF gamma- and INF beta-induced human CXCL11 Gene (Intercrine Alpha/Chemokine CXC Family) in leukocytes, pancreas, liver, astrocytes, thymus, spleen, lung, placenta, prostate, small intestine, and keratinocytes, secreted 94-aa 10-kD ...
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| x (H115D)VHL35 Peptide | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_H115D_VHL35 |
A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor. In (H115D)VHL35 peptide, histidine is substituted for an aspartic acid in position 115. It might be used to elicit or boost...
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| x 117-126:FGF-5 Peptide | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#_117-126_FGF-5_Peptide |
A fragment of fibroblast growth factor-5 (FGF-5). Originally isolated from a renal cell carcinoma cell line that overexpressed FGF-5, FGF-5:117-126 peptide is recognized by tumor infiltrating cytotoxic T lymphocytes. Overexpressed by several cancer...
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| x A and D Ointment | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A_and_D_Ointment |
A topical preparation containing fat-soluble vitamins A and D usually in a lanolin-petrolatum base, A and D Ointment promotes healing of minor burns, rashes, sunburn, skin irritations, and acne; and prevents diaper rash. Vitamin A is essential for...
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| x ADA Transduced T Cell | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#ADA_Transduced_T-Cell |
T cells harvested from a patient with adenosine deaminase (ADA) deficiency and transduced with a vector containing the gene for ADA. ADA catalyzes the hydrolysis of adenosine to inosine; ADA deficiency causes a form of severe combined...
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| x Amygdalin | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Amygdalin |
A cyanogenic glucoside isolated from almonds and seeds of other plants of the family Rosaceae. Amygdalin is converted by plant emulsin (a combination of a glucosidase and a nitrilase) or hydrochloric acid into benzaldehyde, D-glucose, and...
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| x Aphidicoline Glycinate | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Aphidicoline_Glycinate |
A tetracyclic diterpene antibiotic isolated from the fungus Cephalosporium aphidicola and other fungal species with potential antineoplastic activity. Aphidicoline glycinate blocks the cell cycle at early S-phase by specifically inhibiting DNA...
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| x DNA Polymerase Inhibitor | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#DNA_Polymerase_Inhibitor |
An agent that inhibits the function of DNA polymerase, an enzyme that is essential for DNA replication and repair, and subsequently for cell division. By inhibiting DNA polymerase, a DNA polymerase inhibitor induces cell death, especially in the...
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| x Abacavir | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Abacavir_Base |
A synthetic carbocyclic nucleoside analog. In vivo, the activated triphosphate metabolite of abacavir is incorporated into the viral DNA instead of the natural substrate deoxyguanosine, thereby inhibiting human immunodeficiency virus (HIV) reverse...
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| x Acetaminophen/Diphenhydramine | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Acetaminophen_Diphenhydramine |
A synthetic p-aminophenol derivative and diphenhydramine combination with anti-inflammatory, analgesic, and anti-allergic properties. Acetaminophen Diphenhydramine is used to treat symptoms of allergies and hay fever. The active principal metabolite...
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| x Allergy Shot | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Allergy_Shot |
The injection of an allergen extract intended to increase resistance, tolerance, or immunity to the given allergens. When the allergen extract is administered in a series of increasing amounts the process is referred to as allergy therapy,...
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| x Alprostadil | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Alprostadil |
The naturally occuring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in...
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| x Amlodipine Besylate | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Amlodipine_Besylate |
The besylate salt of amlodipine, a synthetic dihydropyridine with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing...
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| x Ammonium Lactate | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Ammonium_Lactate |
An organic salt of ammonium (lactic acid neutralized with ammonium hydroxide), topical moisturizing Ammonium Lactate can be applied as a humectant in ichthyosis vulgaris and xerosis. Available as cream or lotion, this agent moisturizes the skin and...
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| x Petrolatum-Mineral Oil-Lanolin-Ceresin Ointment | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Aquaphor |
A petrolatum-based ointment absorbed by dry and moist skin, petrolatum-mineral oil-lanolin-ceresin ointment is non-comedogenic, non-irritating, and non-sensitizing. It can reduce healing time of cracked, dry skin on hands, elbows, and knees, and...
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| x Argatroban | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Argatroban |
A synthetic derivative of L-arginine with antithrombotic activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin. This agent reversibly binds to the thrombin active site thereby preventing the thrombin-dependent reactions,...
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| x Astemizole | http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Astemizole |
A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non...
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