The InterPro database was established in 1999 when the InterPro Consortium was formed between the SWISS-PROT group at EBI and SIB, and the founding member databases Prints, PROSITE, Pfam and ProDom. The first release was later that year. There are several publications on InterPro, please see: R.Apweiler, T.K.Attwood, A.Bairoch, A.Bateman, E.Birney, M.Biswas, P.Bucher, L.Cerutti, F.Corpet, M.D.R.Croning, R.Durbin, L.Falquet, W.Fleischmann, J.Gouz...
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What is the history of the InterPro project, who established it and when?
The InterPro database was established in 1999 when the InterPro Consortium was formed between the SWISS-PROT group at EBI and SIB, and the founding member databases Prints, PROSITE, Pfam and ProDom. The first release was later that year. There are several publications on InterPro, please see: R.Apweiler, T.K.Attwood, A.Bairoch, A.Bateman, E.Birney, M.Biswas, P.Bucher, L.Cerutti, F.Corpet, M.D.R.Croning, R.Durbin, L.Falquet, W.Fleischmann, J.Gouzy, H.Hermjakob, N.Hulo, I.Jonassen, D.Kahn, A.Kanapin, Y.Karavidopoulou, R.Lopez, B.Marx, N.J.Mulder, T.M.Oinn, M.Pagni, F.Servant, C.J.A.Sigrist, E.M.Zdobnov. The InterPro database, an integrated documentation resource for protein families, domains and functional sites. Nucleic Acids Research vol 29(1):37-40 (2001). and Mulder N.J., Apweiler R., Attwood T.K., Bairoch A., Bateman A., Binns D., Biswas M., Bradley P., Bork P., Bucher P., Copley R., Courcelle E., Durbin R., Falquet L., Fleischmann W., Gouzy J., Griffith-Jones S., Haft D., Hermjakob H., Hulo N., Kahn D., Kanapin A., Krestyaninova M., Lopez R., Letunic I., Pagni M., Peyruc D., Ponting C.P., Servant F. and Sigrist C.J.A. InterPro - An integrated documentation resource for protein families, domains and functional sites. Briefings in Bioinformatics 3(3):285-295 (2002). In this issue there are all papers related to InterPro.
What is InterPro? What is the difference between member databases and matches? InterPro is a consortium of member databases (PROSITE, Pfam, Prints, ProDom, SMART and TIGRFAMs). Each member database devises methods that can be applied computationally to assign a score for a protein according to how well it matches a given signature. For some types of methods, the classification is binary (i.e. hit or miss), in other cases a numerical value is produced and a cut off point chosen to separate hits from misses. Different member databases create methods/signatures in different ways: some groups build them from alignments studied manually, others use automatic processes with some human input and correction, while ProDom use
