Reactome is a database of cellular level processes from simple events, such as biochemical reactions, to complex events, such as the cell cycle. It provides process-level annotation of the structure and function of the Human Genome, with dynamic links to other databases relevant to the human system, and to the relevant literature. Our ontology ensures that the various events are linked in an appropriate spatial and temporal context. The database...
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Reactome is a database of cellular level processes from simple events, such as biochemical reactions, to complex events, such as the cell cycle. It provides process-level annotation of the structure and function of the Human Genome, with dynamic links to other databases relevant to the human system, and to the relevant literature. Our ontology ensures that the various events are linked in an appropriate spatial and temporal context. The database is produced by faculty-level authors, recruited from the biological research community, who write review-style articles on a set of related pathways using a template tool provided by us. The reviews are edited by the staff at CSHL and the EBI, and entered into a relational database. They are then reviewed by other biological researchers for consistency and accuracy. This database was formerly called The Genome Knowledgebase. , Reactome is a curated database of biological processes in humans. It covers biological pathways ranging from the basic processes of metabolism to high-level processes such as hormonal signalling. While Reactome is targeted at human pathways, it also includes many individual biochemical reactions from non-human systems such as rat, mouse, fugu fish and zebra fish. This makes the database relevant to the large number of researchers who work on model organisms. All the information in Reactome is backed up by its provenance: either a literature citation or an electronic inference based on sequence similarity. Our ontology ensures that the various events are linked in an appropriate spatial and temporal context. PThe basic information in Reactome is provided by bench biologists who are experts in that domain of biology. The information is then managed and edited by the Reactome staff at CSHL and the EBI, and entered into a relational database. They are then reviewed by other biological researchers for consistency and accuracy. Following peer-review, the information is published to the web. PReactome supersedes an earlier project called The Genome Knowledgebase and incorporates all the information previously available in its predecessor. Reactome sports a radically redesigned user interface in which the entire set of human pathways known to the database are represented as a series of constellations in a "starry sky." The starry sky can be used to navigate through the universe of human reactions and is invaluable to visualize connections between pathways, some of which will be surprising to biologists who are not familiar with pathways outside their domain of research.
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